Publication: Correlation of cervical cytology with cervical histology
Date
2005
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
Objective: To correlate cervical cytology with Cervical histology. Methodology: A hospital based prospective
study was carried out in consecutive total forty-three patient attending oncology clinic of Kathmandu Medical
College Teaching Hospital, Sinamangal, Nepal from 1st Bhadra 2061 to end of Falgun 2061 (18 th August 2004 - 12 th
February 2005) during authors posting in this clinic. All patients who underwent cervical biopsy on either indication
of clinically suspected lesions or abnormal cytology were correlated with Pap smear report. Pap smear was carried
out in conventional technique using Ayre’s spatula. Cervical biopsy was carried out with help of punch biopsy
forceps in operation Theatre without the guidance of colposcopy. All pertinent information regarding patient profile
in terms of their age, parity, age at marriage, age at 1 st child birth, smoking habit, contraceptive use, and symptom of
vaginal discharge was taken. Reports of Pap smear and cervical biopsy of these patients were collected from
oncology clinic during their follow up visit and all these information and finding were entered in structured
questionnaire. The reporting of Pap smear was done in Bethesda system. The average duration between performing
Pap smear and biopsy was of one month. Statistical analysis was carried out by EPI – INFOS6 system. Result: Of
forty three patients who underwent cervical cytology 22 cases were of Benign lesion, 8 cases of LSIL, 9 cases of
HSIL, 3 cases of invasive carcinoma and 1 of ASCUS. Sensitivity, specificity, positive predictive value, negative
predictive value, diagnostic accuracy and p-value in benign grade was 76%, 83.3%, 86.4%, 71.4%, 79.1%, 0.0004
respectively. Similarly sensitivity, specificity, positive predictive value, negative predictive value, diagnostic
accuracy and p-value in LSIL was 60%, 93.9%, 75%, 88.6%, 86%,0 .0008 respectively. For HSIL it was 100%,
89.5%, 55.6%, 100%, 90.7 0.0001 respectively. Respectively for carcinoma it was 100% for sensitivity, specificity,
positive predictive value, negative predictive value, diagnostic accuracy p-value was0 .00008. Conclusion: Pap
smear significantly correlated with cervical histology.
Key Words: Pap Smear, Histology, Correlation.