Publication: Neonatal Sepsis: A Profile of a Changing Spectrum
| creativeworkseries.issn | ISSN 1990-7974 eISSN 1990-7982 | |
| dc.contributor.author | Venkatnarayan, K | |
| dc.contributor.author | Bej, PK | |
| dc.contributor.author | Thapar, RK | |
| dc.date.accessioned | 2026-03-23T10:54:46Z | |
| dc.date.available | 2026-03-23T10:54:46Z | |
| dc.date.issued | 2014 | |
| dc.description | K Venkatnarayan Department of Paediatrics, Command Hospital (Southern Command), Pune-411040 PK Bej Department of Paediatrics, Command Hospital (Southern Command), Pune-411040 RK Thapar Department of Paediatrics, Command Hospital (Southern Command), Pune-411040 | |
| dc.description.abstract | Abstract: Introduction: The clinical features of neonatal sepsis are protean and are based on variety of clinical, demographic and laboratory profile of suspected cases. Objectives: To describe the aforementioned profiles in neonates presenting with clinically suspected sepsis based on pre-defined clinical criteria. Material and Methods: Design: Cross-Sectional Study; Setting: Level-2 NICU, Tertiary Care Hospital; Duration: Jan 2011 to Jul 2012. Subjects: 50 consecutive neonates presenting with any of the predefined clinical criteria were assessed for presence of maternal risk factors and studied with respect to: Gestational age, sepsis screen, clinical profile and antibiotic sensitivity of the organisms cultured. Results: Out of the fifty neonates, 38 (76%) were early onset sepsis. The sepsis screen showed an overall sensitivity of 73%, specificity of 54%; with a positive predictive value of 41% and a negative predictive value of 83%. The most common organism cultured was Staphylococcus aureus followed by E Coli, Pseudomonas, Coagulase Negative Staphylococcus and Group B Streptococcus. Ampicillin and Amikacin fared better than Cefotaxime and Gentamicin for Gram positive and Gram negative organisms, respectively. Overall, 37 babies responded to first line antibiotics and 11 required a change of antibiotics. One required addition of inotropes and two of the neonates died. Conclusion: A clinical diagnosis of sepsis based on predefined clinical criteria along with maternal risk factors, over- treated 27 babies (71%) with EONS and 8 babies (66.6%) with LONS. However, such a clinical diagnosis was supported by a septic screen almost twice as frequently (50% Vs 26.3%) in LONS. Staphylococcus aureus was the most common organism isolated. | |
| dc.identifier | https://doi.org/10.3126/jnps.v34i3.11236 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14572/5369 | |
| dc.language.iso | en_US | |
| dc.publisher | Nepal Paediatric Society (JNPS) | |
| dc.subject | Sepsis | |
| dc.subject | Neonates | |
| dc.title | Neonatal Sepsis: A Profile of a Changing Spectrum | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| local.article.type | Original Article | |
| oaire.citation.endPage | 214 | |
| oaire.citation.startPage | 207 | |
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