Publication: Efficacy of Intense Pulse Light with Triple Combination Cream Versus Triple Combination Cream alone in the Treatment of Melasma
| creativeworkseries.issn | ISSN 2091-0231 eISSN 2091-167X | |
| dc.contributor.author | Verma, Anshul | |
| dc.contributor.author | Agrawal, Sudha | |
| dc.date.accessioned | 2025-09-21T08:27:11Z | |
| dc.date.available | 2025-09-21T08:27:11Z | |
| dc.date.issued | 2021 | |
| dc.description | Anshul Verma Srishti Hospital & Research Centre, Dibrugarh, Assam, India Sudha Agrawal B.P. Koirala Institute of Health Sciences, Dharan, Nepal | |
| dc.description.abstract | Abstract Introduction: Various studies explored the use of intense pulse light (IPL) therapy in treating melasma, but only a few randomized clinical trials have evaluated the combination of triple combination cream (TCC) with IPL so far. Objective: This study compared the efficacy and safety of the combination of IPL and triple combination cream with triple combination cream alone in treating melasma. Material and Methods: Sixty patients with melasma were enrolled in this assessor-blinded, parallel-group randomized controlled study. Thirty patients were treated with IPL (15J/cm2, two sessions at 2-week intervals) and TCC (Hydroquinone 2%, tretinoin 0.025%, fluocinolone acetonide 0.01%) at night and broad-spectrum sunscreen during day time whereas other groups received only TCC and broad-spectrum sunscreen. The median percentage reduction in melasma area and severity index (MASI) and physician’s global assessment scale was assessed at 12-week to determine the efficacy of the treatment. The incidence of adverse effects at each follow-up and relapse at 16-week were also noted during the study period as the secondary outcome measure. Results: The median reduction in MASI achieved at 12 weeks was 48% in the IPL+TCC group and 13.1% in the TCC group from the baseline. The incidence of relapse was seen in 7.14% and 13.04% patients in the IPL+TCC group and TCC alone group respectively at 16 weeks however, this difference was not statistically significant (p<0.05). Conclusion: Our study supports that IPL and TCC are more effective than TCC therapy alone in treating melasma. Keywords: Intense Pulse Light, Melasma, Triple Combination Cream | |
| dc.identifier | https://doi.org/10.3126/njdvl.v19i2.38557 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14572/2255 | |
| dc.language.iso | en_US | |
| dc.publisher | Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON) | |
| dc.title | Efficacy of Intense Pulse Light with Triple Combination Cream Versus Triple Combination Cream alone in the Treatment of Melasma | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| local.article.type | Original Article | |
| oaire.citation.endPage | 21 | |
| oaire.citation.startPage | 13 | |
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