Publication: Role of C-reactive Protein in Acute Appendicitis
Date
2016
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
Acute appendicitis is the common surgical emergency. This study analyzed the value
of C-reactive protein as the diagnostic marker of acute appendicitis.
Objective
To assess the level of C-reactive protein in acute appendicitis and to relate the
quantitative measurement with degree of inflammation of appendix.
Method
A cross sectional study was done with consecutive patients diagnosed with acute
appendicitis that underwent appendectomy over six months period. Peroperative
findings and histopathology report were compared and analyzed with the level of
C-reactive protein.
Result
A total of 54 patients were enrolled in this study. 94.40% were proved as acute
appendicitis in histopathology. The level of C-reactive protein was significantly raised
among highly inflamed appendix. C-reactive protein showed 84.31% sensitivity,
66.66% specificity, 97.72% positive predictive value and 20% negative predictive
value in diagnosing acute appendicitis.
Conclusion
With degree of inflammation of appendix, value of C-reactive protein was raised.
Quantitative assessment can predict severity of inflammation. Raised level of
C-reactive protein is an aid for diagnosing acute appendicitis.
KEY WORDS
Acute appendicitis, C-reactive protein, Histopathology
Description
Ghimire R, Sharma A, Bohara S
Department of Surgery
Kathmandu Medical College Teaching Hospital,Sinamangal, Kathmandu, Nepal
Keywords
Acute appendicitis, C-reactive protein, Histopathology