Publication: Differentiating Gilbert Syndrome from Crigler Najjar Syndrome Type 2 by Phenobarbitone Test
| creativeworkseries.issn | ISSN 1990-7974 eISSN 1990-7982 | |
| dc.contributor.author | Sinha, R | |
| dc.contributor.author | Dalal, S | |
| dc.contributor.author | Sodhi, K | |
| dc.date.accessioned | 2026-03-23T09:50:27Z | |
| dc.date.available | 2026-03-23T09:50:27Z | |
| dc.date.issued | 2015 | |
| dc.description | R Sinha Department of Pediatrics, Military Hospital Jodhpu S Dalal Department of Paediatrics, AFMC Pune K Sodhi Department of Paediatrics, Command Hospital, Chandigarh | |
| dc.description.abstract | Abstract: Gilbert syndrome characterized by jaundice with intermittent elevations of indirect bilirubin, in the absence of haemolysis or underlying liver disease, has both autosomal dominant and recessive inheritance. Crigler-Najjar syndrome type II (CNS2) is a hereditary disorder of bilirubin metabolism characterized by unconjugated hyperbilirubinemia due to reduced and inducible activity of hepatic bilirubin glucuronosyltransferase (GT). We report 20 children between age 5 to 15 years with unconjugated hyperbilirubenemia who were given seven days of oral phenobarbitone (5mg/kg/day) and decrease in level of bilirubin was noted. There was only 30-40% reduction of bilirubin in Crigler Najjar Syndrome Type 2 compared to Gilberts Syndrome in which bilirubin level normalised. This case series highlights the importance of simple test to differentiate these two conditions. This test is also very helpful in a place where enzyme level and mutational study cannot be done. | |
| dc.identifier | https://doi.org/10.3126/jnps.v35i1.10620 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14572/5360 | |
| dc.language.iso | en_US | |
| dc.publisher | Nepal Paediatric Society (JNPS) | |
| dc.subject | Gilberts | |
| dc.subject | Crigler Najjar | |
| dc.subject | hyperbilirubinemia | |
| dc.title | Differentiating Gilbert Syndrome from Crigler Najjar Syndrome Type 2 by Phenobarbitone Test | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| local.article.type | Case Report | |
| oaire.citation.endPage | 84 | |
| oaire.citation.startPage | 82 | |
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