Publication: Thyroid Angiosarcoma : An unusual and challenging case report at B.P. Koirala Institute of Health Sciences
Date
2025
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Angiosarcoma is an uncommon malignant vascular tumor of endothelial origin and
commonly described in soft tissue. Thyroid is an uncommon site for angiosarcoma
and is a very aggressive tumor commonly occurring in elderly female, characterized
by its prevalence in Alpine regions of central Europe. The main aim of this case
report is to provide an insight on thyroid angiosarcoma (TAS) occurring in non-
Alpine region, to know the major diagnostic features of thyroid angiosarcoma and
distinguish it from anaplastic thyroid carcinoma with angiomatoid features. Due
to its overlapping microscopic features diagnosis of primary thyroid angiosarcoma
(TAS) was challenging. However, the combination of thorough microscopic findings
and immunohistochemical studies (CD 31, Vimentin, Thyroglobulin and Thyroid
Transcription Factor-1) are vitally important in differentiating these two tumors to
achieve at a final diagnosis. This significantly helps to decide the best treatment
option and predict the behaviour.
KEY WORDS
Anaplastic carcinoma, Angiosarcoma, Thyroid gland
Description
Lamichhane U,1 Paudyal P,1 Karki S,1 Pradhan A,1 Dahal M,1 Shah SP2
1Department of Pathology
2Department of ENT
B. P. Koirala Institute of Health Sciences
Dharan, Nepal
Keywords
Anaplastic carcinoma, Angiosarcoma, Thyroid gland