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Hepatitis C Virus Infection in Pregnancy and Children: Its Implications and Treatment Considerations with Directly Acting Antivirals: A Review

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creativeworkseries.issnJNMA Print ISSN: 0028-2715; Online ISSN: 1815-672X
dc.contributor.authorRana, Ramesh
dc.contributor.authorDangal, Rajkumar
dc.contributor.authorSingh, Yogendra
dc.contributor.authorGurung, Ram Bahadur
dc.contributor.authorRai, Bhim
dc.contributor.authorSharma, Amit Kumar
dc.date.accessioned2026-02-17T05:48:46Z
dc.date.available2026-02-17T05:48:46Z
dc.date.issued2021
dc.descriptionRamesh Rana Department of Medicine, Ungoofaaru Regional Hospital, Ungoofaaru, RAA Atoll, Maldives https://orcid.org/0000-0001-6612-9163 Rajkumar Dangal Dolakha Hospital, Kathmandu University-Affiliated Hospital, Dolakha, Nepal Yogendra Singh Department of Medicine, Laligurash Hospital, Talchhikhel-14, Lalitpur, Nepal Ram Bahadur Gurung Department of Medicine and Gastroenterology & Endoscopy Unit Endoscopy Training Center, Dhulikhel Hospital, Kathmandu University School of Medicine, Dhulikhel, Nepal Bhim Rai West Mersea GP Practice, Mersea Island, Colchester, UK https://orcid.org/0000-0001-5953-1576 Amit Kumar Sharma Department of Medicine, Laligurash Hospital, Talchhikhel-14, Lalitpur, Nepal
dc.description.abstractAbstract: Hepatitis C virus infection (HCV) is a global health problem affecting >71 million people worldwide with chronic hepatitis C, 40% reproductive age group, and 8% pregnant women. Intravenous drug abuse, multi-transfusions are major risk factors in adults, while vertical transmission in pediatric population. It commonly presents as a chronic liver disease, has higher risk of liver cirrhosis and even progression to hepatocellular carcinoma. Therefore, proper screening of high-risk populations including pregnancy is recommended. All diagnosed chronic hepatitis C cases should be treated with directly acting anti-virals (DAAs) including pre-conception which has a cure rate of >95%. This would reduce the disease burden, vertical transmission, and disability associated. However, no DAAs regimens recommendation till date due to lack of evidence on adverse fetal outcomes and are concerned about the pharmacokinetic effect regarding physiological changes during pregnancy. Therefore, in this review, we have tried to explore the possible use of DAAs regimens and their safety issues during pregnancy, and possible consideration of few pan-genotypic regimens in the late 2nd and early 3rd trimester. This would not only prevent vertical transmission and decrease disease burden but also help to meet the WHO 2030 target of HCV elimination as a major public health problem.
dc.identifierhttps://doi.org/10.31729/jnma.5501
dc.identifier.urihttps://hdl.handle.net/20.500.14572/4801
dc.language.isoen_US
dc.publisherNepal Medical Association
dc.subjectantiviral agents
dc.subjecthepatitis C virus
dc.subjectinterferon-alpha
dc.subjectpregnancy
dc.subjectreview
dc.subjecttransmission
dc.subjecttreatment
dc.titleHepatitis C Virus Infection in Pregnancy and Children: Its Implications and Treatment Considerations with Directly Acting Antivirals: A Review
dc.typeArticle
dspace.entity.typePublication
local.article.typeReview Article
oaire.citation.endPage953
oaire.citation.startPage942
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relation.isJournalOfPublicatione6e146a0-0ece-4aba-aa0a-6ccfbd10a12a

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