Publication: Ertapenem
Date
2009
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
Abstract
Ertapenem is a parenteral carbapenem licensed for use in adults and children more than 3 months of age. It is active
against many Gram-positive and negative bacteria, including several anaerobic organisms but has a narrower spectrum
of antimicrobial activity, compared with older carbapenems. It is highly stable against nearly all β-lactamases, including
AmpC and extended spectrum beta lactamases. Ertapenem can be given intramuscularly or intravenously and its favourable
pharmacokinetic profile allows once daily dosing. Ertapenem has been proven to be clinically and bacteriologically
efficacious in randomised controlled trials for the treatment of community acquired infections including complicated
intra-abdominal infections, complicated skin and skin-structure infections, acute pelvic infections, complicated urinary
tract infections, community-acquired pneumonia and for the prophylaxis of surgical-site infection following elective
colorectal surgery. Ertapenem is suited for mild to moderately ill patients with community-acquired infections and for
outpatient intravenous antibacterial therapy.
Key words: Antibiotics, Carbapenems, Ertapenem
Description
Parakh A 1, Krishnamurthy S 1 , Bhattacharya M2
1 Lecturer, Department of Paediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India, 2Senior Resident, Department of Paediatrics, Maulana Azad Medical College and Lok Nayak Hospital, India.