Publication: Comparison of Safety Of Oral Ivermectin with Topical Permethrin in the Treatment of Scabies: A Comparative Study
| creativeworkseries.issn | ISSN 2091-0231 eISSN 2091-167X | |
| dc.contributor.author | Tripathee, Rishab Dev | |
| dc.contributor.author | Sitaula, Seema | |
| dc.contributor.author | Kharel, Sanjeev | |
| dc.date.accessioned | 2025-10-08T09:44:28Z | |
| dc.date.available | 2025-10-08T09:44:28Z | |
| dc.date.issued | 2024 | |
| dc.description | Author Biographies Rishab Dev Tripathee, Om Hospital and Research Centre, Kathmandu, Nepal Consultant Dermatologist, Om Hospital and Research Centre, Nepal Seema Sitaula, Department of Dermatology and Venerology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal Assistant Professor, Department of Dermatology and Venerology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal Sanjeev Kharel, Maharajgunj Medical Campus, Tribhuvan University, Kathmandu, Nepal Intern, Maharajgunj Medical Campus, Tribhuvan University, Kathmandu, Nepal | |
| dc.description.abstract | Abstract: Introduction: The mite Sarcoptes scabiei var. hominis is the cause of scabies, a skin illness. The Food and Drug Administration (FDA) approves permethrin cream (5%) for the treatment of scabies and is also recommended by the Centers for Disease Control and Prevention (CDC) as first-line topical therapy for scabies. Oral ivermectin, a novel antiparasitic agent that has been extensively used for several parasitic infections and can be used as an alternative approach for the treatment of scabies. This comparative study aimed to describe the adverse effects of ivermectin and permethrin and their comparison. Objective: To compare the safety outcomes of ivermectin and permethrin for the use of scabies. Methods: This is the prospective open-labeled randomized and comparative study carried out in the outpatient department of dermatology and venereology at Tribhuvan University Teaching Hospital, Kathmandu. In Group A, patients received oral Ivermectin tablets at a dose of 200 μg/kg on day 1 before breakfast, and in Group B, patients received topical Permethrin 5% cream to be applied all over the body below the neck at night twice a week apart. Results: This study included 93 patients who met the inclusion criteria, with 45 patients belonging to the Ivermectin group and 48 patients belonging to the Permethrin group. In the ivermectin group, the most common side effect reported was nausea, followed by abdominal discomfort and headache. In the Permethrin group, the most common side effect was a burning sensation on the skin after application of the drug, followed by irritation and erythema, which were present in 3.2% and 2.2% of patients, respectively. The difference in overall side effects between the two groups was statistically not significant. (p=0.682) Conclusion: Our study concludes that a single dose of oral Ivermectin given at a dose of 200 micrograms/kg is comparable to Permethrin cream 5% used twice a week in terms of safety standards. Neither drug caused any life-threatening adverse reactions in the patients. | |
| dc.identifier | https://doi.org/10.3126/njdvl.v22i1.62576 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14572/2503 | |
| dc.language.iso | en_US | |
| dc.publisher | Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON) | |
| dc.subject | Ivermectin | |
| dc.subject | Permethrin | |
| dc.subject | Scabies | |
| dc.title | Comparison of Safety Of Oral Ivermectin with Topical Permethrin in the Treatment of Scabies: A Comparative Study | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| local.article.type | Original Article | |
| oaire.citation.endPage | 27 | |
| oaire.citation.startPage | 23 | |
| relation.isJournalIssueOfPublication | 30bad17b-0be4-4009-a6cf-dffc34b4fe05 | |
| relation.isJournalIssueOfPublication.latestForDiscovery | 30bad17b-0be4-4009-a6cf-dffc34b4fe05 | |
| relation.isJournalOfPublication | b2ab7aab-75b0-4bd1-9ed0-b8a91c68201a |