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Therapeutic dimensions of ACE inhibitors- A review of literature and clinical trials

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creativeworkseries.issn1812-2027
dc.contributor.authorM, Prabhu
dc.contributor.authorS, Palaian
dc.contributor.authorA, Malhotra
dc.contributor.authorP, Ravishankar
dc.contributor.authorD, Bista
dc.contributor.authorR, Almeida
dc.contributor.authorP, Mishra
dc.date.accessioned2025-07-18T06:03:25Z
dc.date.available2025-07-18T06:03:25Z
dc.date.issued2005
dc.description.abstractIn the 1970s, pharmacological therapy interrupting the renin-angiotensin system was considered beneficial for patients with high-renin hypertension. This gave rise to the development of ACE inhibitors. Surprisingly, the ACE inhibitors proved to be effective not only in patients with high renin hypertension, but also in many patients with normal levels of plasma renin activity. At present ACE inhibitors have a significant position in a wide range of chronic illnesses such as atherosclerosis, hypertension, myocardial infarction, diabetic complications, stroke etc. They are combined safely with drugs like angiotensin receptor blockers, calcium channel blockers and thiazides with varying degree of benefits. Though they are safe drugs, patients need monitoring for renal insufficiency, hypotension, hyperkalemia etc. The safety of these drugs in paediatrics patients is not established. It is better to avoid these drugs during pregnancy. Keywords: ACE inhibitors, Atherosclerosis, Diabetic complications, Hypertension, Myocardial infarction
dc.identifier.urihttps://hdl.handle.net/20.500.14572/369
dc.language.isoen_US
dc.publisherKathmandu University
dc.titleTherapeutic dimensions of ACE inhibitors- A review of literature and clinical trials
dc.typeArticle
dspace.entity.typePublication
local.article.typeReview Article
oaire.citation.endPage304
oaire.citation.startPage296
relation.isJournalIssueOfPublication1440e0da-ef6e-4ab7-8994-4af391c774bf
relation.isJournalIssueOfPublication.latestForDiscovery1440e0da-ef6e-4ab7-8994-4af391c774bf
relation.isJournalOfPublicationa782b7ff-cf89-4178-ad1c-11ed89cfe1bd

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