Publication: Interaction between warfarin and tamoxifen: A case report
Date
2007
Article Type
Case Report
Journal Title
Journal ISSN
1812-2027
Volume Title
Pages
Pages: 105 - 107
Publisher
Kathmandu University
Abstract
Warfarin is a commonly used anticoagulant with documented reports of drug interactions. Tamoxifen is used in the
adjuvant hormonal treatment of women with oestrogen-receptor- positive breast cancer. Warfarin and tamoxifen are
known to interact with each other with a resultant increase in the bleeding tendency. These reports are mainly from
the white population. We report a case of drug interaction between warfarin and tamoxifen with an acute onset. This
report suggests that when these drugs are co administered, careful monitoring of the coagulation profile is needed.
Key words: Drug interaction, Tamoxifen, Warfarin
Description
Mishra D 1, Paudel R 2, Kishore PV 3, Palaian S 4, Bista D 5, Mishra P6
1Medical Intern, 2Lecturer, 3Assistant Professor, 4Lecturer, 5Post graduate student (MSc, Medical Pharmacology),6Assistant Professor, Manipal Teaching Hospital / Manipal College of Medical Sciences Pokhara, Nepal