Publication: Pagetoid Squamous Cell Carcinoma In-Situ of Esophagus
Date
2023
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Squamous cell carcinoma (SCC) is the most common malignant tumor of the
esophagus, however, pagetoid SCCIS is an extremely rare condition in esophagus.1
Pagetoid Squamous Cell Carcinoma In-Situ (SCCIS) has been described in skin and
external genitalia frequently.2 Herein we report a case of pagetoid squamous cell
carcinoma in-situ in a 50-year-old male with clinical information, histopathological
and immunohistochemical findings.
The patient was a 50 years male with dyspepsia,refractory to proton pump
inhibitors (PPIs). In upper gastroduodenal endoscopy, there was no obvious lesion
in the esophagus and only mild erythema was noted. Biopsy showed a surprising
finding of full thickness high grade squamous dysplasia in the lining squamous
epithelium with scattered single large atypical cells. These cells were present away
from the foci of dysplasia. The cells were large and showed marked pleomorphism,
vesicular nuclei, prominent nucleoli and abundant pale to eosinophilic cytoplasm.
Immunohistochemistry (IHC) was positive for p63 and p53, which confirmed the
diagnosis of pagetoid SCCIS.
Pagetoid squamous cell carcinoma in-situ is one of the rare entities with subtle
clinical presentation and endoscopic findings. Evaluation of this case signifies the
importance of taking biopsies in the lesions which shows minimal mucosal change
in the endoscopy.
KEY WORDS
Dysplasia, Endoscopic esophageal biopsies, Immunohistochemistry, Pagetoid,
Squamous cell carcinoma in-situ
Description
Priyadarshinee A,1 Bhattacharya B2
1KIST Medical College and Teaching Hospital
Imadol, Lalitpur, Nepal
2Samyak Pathology Lab
New Baneshwor, Kathmandu, Nepal
Keywords
Dysplasia, Endoscopic esophageal biopsies, Immunohistochemistry, Pagetoid, Squamous cell carcinoma in-situ