Publication: Protection of adrenal and male gonadal functions by androgen in lead-treated rats
| creativeworkseries.issn | 1812-2027 | |
| dc.contributor.author | Biswas, NM | |
| dc.contributor.author | Ghosh, PK | |
| dc.date.accessioned | 2025-07-22T06:31:39Z | |
| dc.date.available | 2025-07-22T06:31:39Z | |
| dc.date.issued | 2006 | |
| dc.description.abstract | The potential health hazard of the large amounts of Lead that occurs in canned baby food, domestic water from lead- lined tanks and, in printing and petroleum industries. Lead acetate administration at a does of 8 mg/kg body weight for 21 days resulted a significant increase in adrenal steroidogenic enzyme (∆5 -3β– HSD) and serum levels of corticosterone, while serum levels of testosterone, FSH, LH and testicular spermatogenesis were decreased in albino rats. But lead-treated rats received exogenous testosterone for the last 14 days of lead treatment, showed prevention of adrenocortical hyperactivity by decreasing adrenal ∆5–3β–HSD activity and serum level of corticosterone. Testosterone administration also increased serum level of testosterone, FSH and LH along with spermatogenesis. The results suggest that testosterone supplementation in lead-treated rats protects adrenocortical activity and testicular spermatogenesis. | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14572/514 | |
| dc.language.iso | en_US | |
| dc.publisher | Kathmandu University | |
| dc.title | Protection of adrenal and male gonadal functions by androgen in lead-treated rats | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| local.article.type | Original Article | |
| oaire.citation.endPage | 221 | |
| oaire.citation.startPage | 218 | |
| relation.isJournalIssueOfPublication | 2571981e-5785-4142-970b-863aa4219be4 | |
| relation.isJournalIssueOfPublication.latestForDiscovery | 2571981e-5785-4142-970b-863aa4219be4 | |
| relation.isJournalOfPublication | a782b7ff-cf89-4178-ad1c-11ed89cfe1bd |