Publication: Prevalence of Anti-Thyroid Peroxidase Antibody in Hypothyroid Patients Visiting Western Regional Hospital: A Cross-Sectional Study
| creativeworkseries.issn | eISSN: 3102-0194 pISSN: 3102-0186 | |
| dc.contributor.author | Bastola, Basanta Kumar | |
| dc.contributor.author | Suresh, Thapa | |
| dc.contributor.author | Regmi, Kiran | |
| dc.contributor.author | Hamal, Surya Bahadur | |
| dc.contributor.author | Poudel, Rajendra | |
| dc.contributor.author | Sharma, Soniya | |
| dc.date.accessioned | 2025-12-28T09:46:00Z | |
| dc.date.available | 2025-12-28T09:46:00Z | |
| dc.date.issued | 2025 | |
| dc.description | Basanta Kumar Bastola Department of Internal Medicine, Nepal APF Hospital, Balambu , Kathmandu, Bagmati, Nepal Author https://orcid.org/0009-0007-7902-8805 Suresh Thapa Department of Internal Medicine, Pokhara Academy of Health Sciences, Pokhara, Gandaki, Nepal Author https://orcid.org/0000-0002-4468-3988 Kiran Regmi Department of Internal Medicine, Pokhara Academy of Health Sciences, Pokhara, Gandaki, Nepal Author https://orcid.org/0009-0004-1306-9557 Surya Bahadur Hamal Department of Internal Medicine, Pokhara Academy of Health Sciences, Pokhara, Gandaki, Nepal Author https://orcid.org/0000-0002-1825-0097 Rajendra Poudel Department of Internal Medicine, Pokhara Academy of Health Sciences, Pokhara, Gandaki, Nepal Author https://orcid.org/0000-0002-5288-1028 Soniya Sharma Deparment of Radiology, Kathmandu Medical College, Kathmandu, Bagmati, Nepal Author https://orcid.org/0009-0003-0260-3200 | |
| dc.description.abstract | Abstract: Introduction: Hypothyroidism is a common endocrine disorder with autoimmune thyroiditis increasing as a major cause, especially in iodine-sufficient areas. Anti-thyroid peroxidase (antiTPO) antibodies are important markers of autoimmune thyroid disease. The objective of this study to determine the prevalence of anti-TPO antibodies in hypothyroid patients and their correlation with the type of hypothyroidism, age, gender, and clinical presentation. Methods: This analytical cross-sectional study was conducted among 73 hypothyroid patients attending the OPD and medical ward of Western Regional Hospital (WRH), a tertiary care centre in Gandaki Province. Demographic and clinical data were collected. Laboratory assessments included thyroid function tests and anti-TPO levels using chemiluminescence immunoassay. Descriptive and inferential statistics were applied using SPSS v27. Results: Among 73 participants (mean age 42.1 ± 12.07 years), 81% were female. Anti-TPO antibodies were positive in 38% of patients. Among patients with overt hypothyroidism, 41% were anti-TPO positive, while 36% of subclinical hypothyroidism patients had anti-TPO positivity. No statistically significant associations were found between anti-TPO status and gender (p=0.821), type of hypothyroidism (p=0.666), or age group (p=0.24). Likewise, the common presenting signs and symptoms did not have statistically significant association with the TPO positivity status. Conclusion: Over one-third of hypothyroid patients had anti-TPO antibody positivity, with a slightly higher prevalence in overt hypothyroidism. However, demographic and clinical variables did not significantly correlate with antibody status. | |
| dc.identifier | https://doi.org/10.64772/mjapfn111 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14572/3937 | |
| dc.language.iso | en_US | |
| dc.publisher | Nepal APF Hospital | |
| dc.subject | Anti-thyroid peroxidase antibody | |
| dc.subject | Autoimmune thyroiditis | |
| dc.subject | Hypothyroidism | |
| dc.subject | Subclinical hypothyroidism | |
| dc.subject | Thyroid function test | |
| dc.title | Prevalence of Anti-Thyroid Peroxidase Antibody in Hypothyroid Patients Visiting Western Regional Hospital: A Cross-Sectional Study | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| local.article.type | Original Article | |
| oaire.citation.endPage | 6 | |
| oaire.citation.startPage | 1 | |
| relation.isJournalIssueOfPublication | b2731616-67b4-4397-80d3-543c049b8fb8 | |
| relation.isJournalIssueOfPublication.latestForDiscovery | b2731616-67b4-4397-80d3-543c049b8fb8 | |
| relation.isJournalOfPublication | c3f8fb47-0af9-4971-9219-d9e47cec6cd5 |