Publication:
Role of Tocilizumab in the Treatment of COVID-19 Patients with Cytokine Storm: A Case Series

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creativeworkseries.issnJNMA Print ISSN: 0028-2715; Online ISSN: 1815-672X
dc.contributor.authorBasnet, Ajaya
dc.contributor.authorShrestha, Mahendra Raj
dc.contributor.authorThapa, Rossu
dc.contributor.authorTamang, Basanta
dc.contributor.authorShrestha, Apurba
dc.contributor.authorRawal, Prabhat
dc.contributor.authorShrestha, Sailendra Kumar Duwal
dc.contributor.authorKarki, Lochan
dc.contributor.authorRai, Shiba Kumar
dc.date.accessioned2025-12-07T07:19:25Z
dc.date.available2025-12-07T07:19:25Z
dc.date.issued2022
dc.descriptionAjaya Basnet Department of Medical Microbiology, Shi-Gan International College of Science and Technology, Maharajgunj, Kathmandu, Nepal Mahendra Raj Shrestha Department of Clinical Laboratory, Nepal Armed Police Force Hospital, Balambu, Kathmandu, Nepal Rossu Thapa Department of Radiology, Nepal Armed Police Force Hospital, Balambu, Kathmandu, Nepal Basanta Tamang Department of Clinical Laboratory, Nepal Armed Police Force Hospital, Balambu, Kathmandu, Nepal Apurba Shrestha Department of Internal Medicine, Nepal Armed Police Force Hospital, Balambu, Kathmandu, Nepal Prabhat Rawal Department of Anaesthesiology and Critical Care, Nepal Armed Police Force Hospital, Balambu, Kathmandu, Nepal Sailendra Kumar Duwal Shrestha Department of Orthopedic and Trauma Services, Nepal Armed Police Force Hospital, Balambu, Kathmandu, Nepal Lochan Karki Department of Medicine, National Academy of Medical Sciences, Bir Hospital, Mahaboudha, Kathmandu, Nepal Shiba Kumar Rai Research Department, Nepal Medical College and Teaching Hospital, Jorpati, Kathmandu, Nepal
dc.description.abstractAbstract The in-hospital mortality in patients with COVID-19 could be correlated with severe acute respiratory syndrome coronavirus-2 induced hyper-inflammation, which is attributed to an unconstrained inflammatory cytokine storm. The pro-inflammatory cytokine, specifically, interleukin-6 plays a prominent role in the cytokine storm and may result in alveolar-capillary blood-gas exchange dysfunction. Therefore, the method to block the signal transduction pathway of interleukin-6 could be a potential treatment for severe COVID-19 patients. In this case series of three patients with severe COVID-19, we focus on the rationale for utilization of tocilizumab, an anti-interleukin-6 receptor antibody, which could block the signal transduction pathway of interleukin-6. The observations from this study allowed us to hypothesize that the infusions of tocilizumab may not reduce the elevated level of interleukin-6, and hence may not be a significant therapeutic for reducing in-hospital mortality associated with COVID-19. Additionally, it could also be speculated that interleukin-6 may not be a potentially actionable target cytokine to treat COVID-19-associated cytokine storms.
dc.identifierhttps://doi.org/10.31729/jnma.7364
dc.identifier.urihttps://hdl.handle.net/20.500.14572/3433
dc.language.isoen_US
dc.publisherNepal Medical Association
dc.subjectCOVID-19
dc.subjectCytokines
dc.subjectInterleukin-6
dc.titleRole of Tocilizumab in the Treatment of COVID-19 Patients with Cytokine Storm: A Case Series
dc.typeOther
dspace.entity.typePublication
local.article.typeCase Report
oaire.citation.endPage731
oaire.citation.startPage727
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