Publication: Investigating the Efficacy of Triple Drug Therapy and Sequential Drug Therapy in the Eradication of Helicobacter Pylori with Respect to Antigen Stool test: A Pilot Study
Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
Helicobacter pylori is one of the most prevalent infectious disease worldwide. The
treatment regimens involve mainly two therapies: Standard Triple drug therapy and
Sequential drug therapy. Several studies have shown that the sequential therapy
has higher eradication rates of H. pylori than the standard triple drug therapy and
since proper study on sequential drug therapy and standard triple drug therapy is
still lacking in Nepal, this study is attempted to compare efficacy of Sequential Drug
Therapy in the eradication of H. pylori in gastritis with respect to the Standard triple
drug therapy.
Objective
To investigate the efficacy of Triple Drug Therapy and Sequential Drug Therapy in the
eradication of Helicobacter pylori with respect to Antigen Stool test.
Method
This study was the prospective study conducted in 62 patients attending the
Department of Gastroenterology, Dhulikhel Hospital, meeting the inclusion criteria
who were confirmed as H. pylori positive by histopathology and stool antigen test.
Patients were randomized into two groups. One group prescribed with Standard
triple drug regimen and another group with Sequential drug regimen. Eradication
of H. pylori infection was confirmed by repeating the stool antigen test at least five
weeks after the completion of the regimen.
Result
Among the 62 participants included in this study, 54.5% of them were males. Among
the study population, the eradication achieved by standard triple drug therapy was
87.8% and 89.6% with Sequential drug therapy. Higher numbers (82.3%) of patients
were compliant to the prescribed medication. Forgetfulness was the main reason for
missing the dose (91%) of the non-compliant patients.
Conclusion
The study revealed an equal efficacy of both Standard Triple drug regimen and
Sequential drug regimen in the eradication of H. pylori infection. Further, Stool
antigen test can be preferred as a non-invasive test, for diagnosis of H. pylori infection,
monitoring the response to treatment and in epidemiological studies.
KEY WORDS
Helicobacter pylori, Sequential drug therapy, Stool antigen test, Triple drug therapy
Description
Shrestha R,1,2 Poudel R,3 Shakya S,1 Gurung RB,4 Makaju R,5 Koju P2
1Department of Pharmacology,
2Pharmacovigillance Unit/ Research & Development Division,
Dhulikhel Hospital, Kathmandu University Hospital,
Dhulikhel, Kavre.
3Department of Pharmacology, Nepal Medical
College, Jorpati, Kathmandu.
4Department of Internal Medicine,
5Department of Pathology,
Kathmandu University School of Medical Sciences,
Dhulikhel Hospital, Kathmandu University Hospital,
Dhulikhel, Kavre
Keywords
Helicobacter pylori, Sequential drug therapy, Stool antigen test, Triple drug therapy