Publication: Relationship between T lymphocyte subsets and cortisol in systemic lupus erythematosus
| creativeworkseries.issn | 1812-2027 | |
| dc.contributor.author | Shah, D | |
| dc.contributor.author | Kiran, R | |
| dc.contributor.author | Wanchu, A | |
| dc.contributor.author | Bhatnagar, A | |
| dc.date.accessioned | 2025-08-06T06:22:56Z | |
| dc.date.available | 2025-08-06T06:22:56Z | |
| dc.date.issued | 2009 | |
| dc.description | Shah D 1, Kiran R1, Wanchu A 2, Bhatnagar A 1 Department of Biochemistry1, Basic Medical Science Block, Panjab University, Chandigarh, India, Department of Internal Medicine2 , Postgraduate Institute of Medical Education and Research, Chandigarh, India. | |
| dc.description.abstract | Abstract Background: Systemic Lupus Erythematosus (SLE) is a complex chronic immunological disease characterized by increased B cell activity and altered T cell function. Objective: To investigate relationship between T lymphocyte subsets and cortisol with the disease activity of systemic lupus erythematosus patients in North India. Materials and methods: The percentage of CD4+ and CD8+ T cells in the lymphocyte of SLE patients and healthy controls were determined by flow cytometry. Serum cortisol of SLE patients and healthy controls was determined by enzyme-linked immunosorbent assay (ELISA). Results: A significant decrease in the percentage of CD4+ T cells and increase in the percentage of CD8+ T cells were found in patients with SLE compared to the healthy controls. Decrease in the ratio of CD4+/CD8+ T cell and low level of serum cortisol were found in the patients with SLE. The ratio of CD4+/CD8+ T cell was inversely correlated with systemic lupus erythematosus disease activity index (SLEDAI) score and erythrocyte sedimentation rate (ESR). A positive correlation was observed between CD8+ T cells and SLEDAI score. Furthermore, CD8+ T cells were positively correlated with ESR in the patients with SLE. Conclusion: The results showed that low level of cortisol and high percentage of CD8+ T cells in the lymphocytes could be actively involved in the pathogenesis of SLE. Key words: CD4+/CD8+ T cell ratio, cortisol, systemic lupus erythematosus, T-cell activation | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14572/1294 | |
| dc.language.iso | en_US | |
| dc.publisher | Kathmandu University | |
| dc.title | Relationship between T lymphocyte subsets and cortisol in systemic lupus erythematosus | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| local.article.type | Original Article | |
| oaire.citation.endPage | 219 | |
| oaire.citation.startPage | 213 | |
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