Publication: Study of Prescription Pattern and Factors Associated with Clinical Outcomes in Type 2 Diabetes Mellitus with Reference to Short Term Glycemic Control
Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
Diabetes is a chronic disease that occurs either when the pancreas does not produce
enough insulin or when the body cannot effectively use the insulin it produces.
Though oral hypoglycemic agents (OHAs) or/and insulin are prescribed to control
the hyperglycemia, still glycemic control is not seen in most of the cases. Evaluating
the treatment pattern including the glycemic control and associated factors are of
utmost importance for better patient care.
Objective
To investigate the treatment pattern and short term glycemic control among Type 2
Diabetes Mellitus (DM2) patients and study the factors associated with it.
Method
Patients meeting the inclusion criteria with DM2 attending laboratory or Out-Patient
Department or Emergency Department in Dhulikhel Hospital and patients who were
admitted to the ward taking various OHAs and/or insulin at the time of data collection
were considered. Informed consent was taken prior to the interview. The collected
data was entered as well as analyzed using the SPSS (Statistical Package for Social
Sciences) version 21.0 and the p-value <0.05 was considered statistically significant.
Result
Among the 118 patients, 50.8% of them were males. Majority (28%) of the patients
belonged to the age group of 51-60 years. Out of the 118 patients, 22% had their
fasting blood glucose (FBG) level under control whereas 78% had uncontrolled
FBG level. Metformin was the most (28%) commonly prescribed drug. Significant
association was found between gender; knowledge about disease and medication
with short term glycemic control (p=0.034, p=0.004 ans p=0.039 respectively).
Conclusion
All the patients enrolled in this study were under various anti-diabetic medications,
however, majority of them didn’t have their glycemia under control. Significant
association was found between FBG level and gender, knowledge about disease and
knowledge about medication.
KEY WORDS
Diabetes, Glycemic control, Insulin, Oral hypoglycemic agents
Description
Shakya Shrestha S,1,2 Palanchoke S,1 Shrestha R,1,2 Bhatta RD3
1Department of Pharmacology,
2Pharmacovigilance Unit,
Research and Development Division,
3Department of Clinical Biochemistry,
Kathmandu University School of Medical Sciences
Dhulikhel, Kavre, Nepal.
Keywords
Diabetes, Glycemic control, Insulin, Oral hypoglycemic agents