Publication: Study of sensitivity and specificity of five rapid plasma reagin test kits in syphilis
Files
Date
2007
Authors
Article Type
Original Article
Journal Title
Journal ISSN
ISSN (Print) : 1993-2979 | ISSN (Online) : 1993-2987
Volume Title
Pages
Pages: 34 - 36
Publisher
Institute of Medicine
Abstract
Abstract
Background: Syphilis caused by Treponema pallidum has been associated with humankind since ancient times.
Materials and Methods: Blood samples from 408 healthy Nepalese male population was collected and tested to find out the sensitivity and specificity of five different (a, b, c, d and e) non treponemal syphilis serological test rapid plasma reagin (RPR) as well as for the screening of the healthy target group for syphilis.
Results: Six subjects (1.47%) were found positive with the test and by Treponema pallidum Haemagglutination (TPHA) test was identified as a syphilitic subject. With the test kits a, c and d 34 false positive cases were detected. The sensitivity was 100%, and the specificity was 92% only. Whereas with test kits b and e only six true positive cases were detected thus making their sensitivity and specificity 100%.
Conclusion: Therefore, it is concluded that test kits a, c and d should only be used for the screening purpose. On the other hand, the test kits b and e can be used for the diagnostic purpose.
Keywords: RPR, TPHA, syphilis, sensitivity, specificity
Description
B. Shrestha
Department of Microbiology Tribhuvan University Tri-Chandra Campus
Keywords
RPR, TPHA, syphilis, sensitivity, specificity
Identifier
https://doi.org/10.59779/jiomnepal.278