Article: Acetaminophen induced Stevens Johnson syndrome - Toxic Epidermal Necrolysis Overlap Syndrome: A rare Adverse Reaction
Abstract:
Stevens Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are hyper sensitive life - threatening rare dermatological reactions. In SJS - TEN overlap syndrome, the extent and severity of epidermal detachment is 10- 30%. Drugs like sulfonamides, nonsteroidal anti- inflammatory agents, antibiotics and anticonvulsants are the commonest precipitants. Here, we present a rare case of SJS - TEN overlap syndrome in a previously normal 11 years old girl after acetaminophen intake for fever. This case report is intended to make paediatricians aware that the adverse reaction like SJS - TEN overlap syndrome can develop with a drug like acetaminophen which is supposed to be the safest antipyretic in paediatrics.
Saiprasad Onkareshwar Kavthekar
Department of Paediatrics, D.Y. Patil Medical College, D. Y. Patil Education Society (Deemed to be University), Kolhapur- 416003, Maharashtra, India
K. Amith
Department of Paediatrics, D.Y. Patil Medical College, D. Y. Patil Education Society (Deemed to be University), Kolhapur- 416003, Maharashtra, India
Anil Bapurao Kurane
Department of Paediatrics, D.Y. Patil Medical College, D. Y. Patil Education Society (Deemed to be University), Kolhapur- 416003, Maharashtra, India.
Yoganand J Phulari
Department of Dermatology, D.Y. Patil Medical College, D. Y. Patil Education Society (Deemed to be University), Kolhapur- 416003, Maharashtra, India.
Keywords
Acetaminophen, Child, Toxic Epidermal Necrolysis, Steven-Johnson Syndrome
Identifier
https://doi.org/10.3126/jnps.v42i1.39225
Citation
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