Publication: C–reactive Protein and Early Mortality in Acute Ischemic Stroke
Date
2011
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
There is growing evidence that inflammation plays an important role in
atherogenesis. Several studies have shown that C-reactive protein (CRP), an
inflammatory marker, is associated with stroke severity and outcome. But limited
studies are there which show the relationship of CRP with early mortality i.e within
seven days.
Objective
To study the association of CRP within 24 hours after acute ischemic stroke onset
with severity during admission, types of ischemic stroke and outcome.
Methods
This cross sectional study was done including 100 consecutive cases of acute
ischemic stroke admitted to Neurology center of College of Medical Sciences,
Bharatpur (Chitwan), Nepal. The cases were classified as per TOAST classification
and severity at admission assessed using National Institutes of Health Stroke Scale.
C-reative protein (CRP) level was estimated by latex particle agglutination test.
Result
Thirteen percent patients expired by 7th day. In the expired group, CRP was
positive in 15.3 percent, 15.3 percent and 61.5 percent in patients with lacunar,
cardioembolic and large artery atherosclerotic infarction respectively (p 0.19). CRP
was positive in all 7 patients (53.8%) who had expired with severe NIHS scale (p
0.004).
Conclusion
High CRP level is associated with stroke severity at admission and is an independent
predictor of early seven day mortality after ischemic stroke
KEY WORDS
atherosclerosis, C-reactive protein, cardioembolic. ischemic stroke, lacunar
Description
Dewan KR, Rana PVS
Department of Medicine and Neurology College of Medical Sciences Bharatpur, Chitwan Dist, Nepal