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Mean Serum Creatine Kinase among Organophosphate Poisoning Cases in a Tertiary Care Centre: A Descriptive Cross-sectional Study

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creativeworkseries.issnJNMA Print ISSN: 0028-2715; Online ISSN: 1815-672X
dc.contributor.authorTwayana, Saru
dc.contributor.authorSharma, Vijay Kumar
dc.contributor.authorRaut, Mithileshwor
dc.contributor.authorBhattarai, Aseem
dc.contributor.authorYadav, Binod Kumar
dc.contributor.authorBajracharya, Sangha Ratna
dc.contributor.authorTuladhar, Eans Tara
dc.date.accessioned2025-11-10T06:17:52Z
dc.date.available2025-11-10T06:17:52Z
dc.date.issued2022
dc.descriptionSaru Twayana Department of Biochemistry, Maharajgunj Medical Campus, Maharajgunj, Kathmandu, Nepal Vijay Kumar Sharma Department of Biochemistry, Maharajgunj Medical Campus, Maharajgunj, Kathmandu, Nepal Mithileshwor Raut Department of Biochemistry, Maharajgunj Medical Campus, Maharajgunj, Kathmandu, Nepal Aseem Bhattarai Department of Biochemistry, Maharajgunj Medical Campus, Maharajgunj, Kathmandu, Nepal Binod Kumar Yadav Department of Biochemistry, Maharajgunj Medical Campus, Maharajgunj, Kathmandu, Nepal Sangha Ratna Bajracharya Department of Pharmacology, Maharajgunj Medical Campus, Maharajgunj, Kathmandu, Nepal Eans Tara Tuladhar Department of Biochemistry, Maharajgunj Medical Campus, Maharajgunj, Kathmandu, Nepal
dc.description.abstractAbstract Introduction: Major cases of poisoning are associated with organophosphates. Cholinergic effects and an intermediate phase seen with organophosphate poisoning may implicate myopathy. Creatine kinase is a marker of muscle tissue damage. This study aimed to find out the mean serum creatine kinase among organophosphate poisoning cases in a tertiary care centre. Methods: A descriptive cross-sectional study was carried out among organophosphate poisoning cases in a tertiary care hospital from 13 October 2017 to 30 March 2018. Ethical approval was taken from the Institutional Review Committee [Reference number: 117(6-11-E) 2/074/075]. Blood samples were assayed for serum acetylcholinesterase in the pharmacology laboratory and for serum creatine kinase and lactate dehydrogenase in the biochemistry laboratory. Low serum acetylcholinesterase was taken as the basis for the establishment of organophosphate poisoning. A convenience sampling technique was used. Point estimate and 95% Confidence Interval were calculated. Results: Among 103 organophosphate poisoning cases, the mean serum creatine kinase was 931.35±446.60 IU/l (845.10-1017.60, 95% Confidence Interval). Conclusions: The mean serum creatine kinase level among organophosphate poisoning cases was higher than in other studies done in similar settings.
dc.identifierhttps://doi.org/10.31729/jnma.7692
dc.identifier.urihttps://hdl.handle.net/20.500.14572/3105
dc.language.isoen_US
dc.publisherNepal Medical Association
dc.subjectAcetylcholinesterase
dc.subjectCreatine kinase
dc.subjectOrganophosphate poisoning
dc.subjectRhabdomyolysis
dc.titleMean Serum Creatine Kinase among Organophosphate Poisoning Cases in a Tertiary Care Centre: A Descriptive Cross-sectional Study
dc.typeArticle
dspace.entity.typePublication
local.article.typeOriginal Article
oaire.citation.endPage883
oaire.citation.startPage881
relation.isJournalIssueOfPublication3668fd65-4a8c-4e92-a7cc-aa6ea7518d82
relation.isJournalIssueOfPublication.latestForDiscovery3668fd65-4a8c-4e92-a7cc-aa6ea7518d82
relation.isJournalOfPublicatione6e146a0-0ece-4aba-aa0a-6ccfbd10a12a

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