Publication: Correlation of Calcium, Phosphorus, Uric Acid and Magnesium Level in Serum and 24 hours Urine of Patients with Urolithiasis
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Date
2011
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Bakcground
Urinary stones disease is common pathology encountered in urological practice
in Nepal. Supersaturated urine and its stagnation are well known facts for
the development of urolithiasis. Metabolic disorders like hypercalciuria,
hyperuricaemia, hypocitraturia are also responsible for formation of urolithiasis.
Objective
The aim of this study was to identify the level of calcium, phosphorus, uric acid, and
magnesium in the blood and urine of Nepalese patients with urinary stones.
Methods
This study was conducted over a period of six months (From May to November
2010). It is a descriptive cross sectional study and quantitative method was used for
analysis. Primary data were collected and utilized from 79 cases.
Results:
The prevalence of urolithiasis in male patients was 65.8% and 34.2% in female
patients (p<0.05). Serum calcium in stone former and non-stone former was
8.3±1.2 and 7.5±1.5 (p<0.01) respectively. Serum phosphorus and uric acid in both
groups were statistically not significant (p value 0.269 and 0.597 respectively)
though in 24 hours urine of stone formers value of phosphorus was 447.9±182.4
but in non-stone formers it was 186.5±118.7 (p<0.001). Magnesium level in urine
was 48.1±69.7 and 131.4±86.9 (p<0.001) respectively.
Conclusion
Higher level of calcium in serum was found in patients with urolithiasis in our
population. Though phosphate level in blood serum was not different in the both
groups but in urine phosphate and magnesium levels were significantly different.
KEY WORDS
hypercalciuria, hyperphosphaturia, hyperuricosuria, hypocitraturia, urolithiasis
Description
Gyawali PR, Joshi BR, Gurung CK
Department of Urology Tribhuwan University Teaching Hospital Maharajgunj, Kathmandu.