Publication:
Clinicopathological Profile of Dengue Infection in a Tertiary Care Centre in Nepal

Simple item page
creativeworkseries.issn1999-6217
dc.contributor.authorThapa, Bibechan
dc.contributor.authorPandey, Aakriti
dc.contributor.authorGautum, Santosh
dc.contributor.authorKC, Sajana
dc.contributor.authorChhetri, Prabha Devi
dc.contributor.authorPokhrel, Estory
dc.contributor.authorPoudel, Sangeeta
dc.contributor.authorShankar, P Ravi
dc.date.accessioned2025-08-05T06:20:00Z
dc.date.available2025-08-05T06:20:00Z
dc.date.issued2022
dc.descriptionBibechan Thapa Department of Paediatrics, KIST Medical College and Teaching Hospital, Lalitpur, Nepal Aakriti Pandey Department of Emergency Medicine, KIST Medical College and Teaching Hospital, Lalitpur, Nepal Santosh Gautum Department of Internal Medicine, KIST Medical College and Teaching Hospital, Lalitpur, Nepal Sajana KC Department of Internal Medicine, KIST Medical College and Teaching Hospital, Lalitpur, Nepal, Prabha Devi Chhetri Department of Paediatrics, KIST Medical College and Teaching Hospital, Lalitpur, Nepal Estory Pokhrel Department of Emergency Medicine, Nidan Hospital, Lalitpur, Nepal Sangeeta Poudel Department of Emergency Medicine, Banepa Hospital, Lalitpur, Nepal P Ravi Shankar IMU Centre for Education, International Medical University, Kuala Lumpur, Malaysia https://orcid.org/0000-0001-6105-5636
dc.description.abstractAbstract Background:Dengue is a mosquito-borne viral disease with a wide spectrum of presentations ranging from subclinical disease to severe dengue. Dengue is endemic to the Terai of Nepal. Interestingly, an increasing incidence has been reported from hilly areas like Kathmandu valley. This study explored the clinicopathological profile of dengue infection. Methods:A total of 84 serologically confirmed dengue cases from September to November 2019 at KIST Medical College were recruited in a cross-sectional study after obtaining ethical approval. Dengue was categorized as dengue without warning signs, dengue with warning signs, and severe dengue. Clinicopathological information was recorded in the proforma by reviewing patients’ records. A descriptive statistical tool and chi-square test were carried out. Results: Out of 84 patients, 76% (64) were dengue without warning signs, 21.4% (18) were dengue with warning signs and 2.4% (2) were severe dengue. About 97.6% (82) presented with fever. During the course of illness, anemia was identified in 38.1% (32), thrombocytopenia in 65.5% (55), hemoconcentration in 6% (5), and leucopenia in 82.1% (69). Similarly, elevated aspartate transaminase and alanine transaminase (ALT) was observed in 67.7% (42) and 53.2% (33) respectively. The severity of dengue on presentation to hospital was significantly associated with thrombocytopenia, leucopenia, and elevated ALT. Similarly, the severity during course of illness in hospital was significantly associated with hemoconcentration, thrombocytopenia, leucopenia, and elevated ALT. Conclusions: Most common presentation of dengue infection was fever. The most common laboratory abnormalities were leucopenia, thrombocytopenia, hemoconcentration, anemia, and elevated liver enzymes. Awareness of these clinical and laboratory parameters is important for the prompt diagnosis, severity estimation, and overall management of dengue infection. Keywords: Biochemical; dengue; hematological; Nepal; serological
dc.identifierhttps://doi.org/10.33314/jnhrc.v20i4.4172
dc.identifier.urihttps://hdl.handle.net/20.500.14572/1252
dc.language.isoen_US
dc.publisherNepal Health Research Council
dc.titleClinicopathological Profile of Dengue Infection in a Tertiary Care Centre in Nepal
dc.typeArticle
dspace.entity.typePublication
local.article.typeOriginal Article
oaire.citation.endPage867
oaire.citation.startPage859
relation.isJournalIssueOfPublicationbab336f9-a344-4947-87ff-8532a3808cc5
relation.isJournalIssueOfPublication.latestForDiscoverybab336f9-a344-4947-87ff-8532a3808cc5
relation.isJournalOfPublication40bd2739-8b19-447c-be60-723a1bdd1dcd

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
859-867.pdf
Size:
280.19 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.86 KB
Format:
Item-specific license agreed to upon submission
Description:
Download

Collections

Publications

Connect with us

Nepal Health Research Council © 2023
Ramshah Path, Kathmandu Nepal P.O.Box 7626