Publication: Clinical Profile of Neonatal RSV Bronchiolitis - A Descriptive Study
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Date
2025
Journal Title
Journal ISSN
Volume Title
Publisher
Perinatal Society of Nepal (PESON)
Abstract
Abstract:
Introduction: Newborns with viral bronchiolitis may have a turbulent clinical course and Respiratory syncytial virus (RSV) is the most common viral agent causing bronchiolitis in childhood.
Methods: This ambispective study was conducted in the outborn nursery of a tertiary care Government Medical College in neonates who were admitted with a working diagnosis of acute bronchiolitis or respiratory tract infection. A retrospective chart review was done for the cases admitted during the outbreaks of August to November 2022 and a prospective study was done from September to December 2023.
Results: During the study period, a total of 100 neonates (60 cases in 2022 and 40 cases in 2023) were admitted with respiratory tract infection or bronchiolitis. 75% of the babies had moderate to severe bronchiolitis. Thirteen babies with severe bronchiolitis required invasive ventilation. The most common virus detected was RSV followed by Rhino virus. Among the neonates with RSV infection, 65.71% were term babies. There was no mortality. The most common clinical presentation was cough (N =89) (89%) and the threatening symptom was apnea with cardiorespiratory arrest. Remedesivir, an antiviral agent, was given to two babies with severe RSV bronchiolitis on compassionate ground.
Conclusions: Apnea and cardiorespiratory arrest should be anticipated in neonatal bronchiolitis. Remdesivir is an antiviral agent which can be life saving in severe RSV bronchiolitis.
Description
Aswathy Rahul
Assistant Professor in Neonatology, Department of Neonatology, Government Medical College, Thiruvananthapuram, Kerala, India
Aishwarya Venugopal
Senior Resident in Neonatology, Department of Neonatology, Government Medical College, Thiruvananthapuram, Kerala, India
Raunak Raj
Consultant Neonatologist, Rani Hospital, Ranchi, India
Athul Padmanabhan
Senior Resident in Neonatology, Department of Neonatology, Government Medical College, Thiruvananthapuram, Kerala, India
Meghna Nema
Senior Resident in Neonatology, Department of Neonatology, Government Medical College, Thiruvananthapuram, Kerala, India.
Radhika Sujatha
Professor, Department of Neonatology, Government Medical College, Thiruvananthapuram, Kerala, India
Keywords
Antiviral agents, Neonate, Remdesivir, Respiratory infections