Article: Correlates of Selected Biochemical Markers of Bone turnover among Post-Menopausal Women
| creativeworkseries.issn | JNMA Print ISSN: 0028-2715; Online ISSN: 1815-672X | |
| dc.contributor.author | Khadka, Bikram | |
| dc.contributor.author | Tiwari, Mohan Lal | |
| dc.contributor.author | Gautam, Ravi | |
| dc.contributor.author | Timalsina, Binod | |
| dc.contributor.author | Pathak, Nandu Prasad | |
| dc.contributor.author | Kharel, Krishna | |
| dc.contributor.author | Sharma, Shanta | |
| dc.contributor.author | Acharya, Dilaram | |
| dc.date.accessioned | 2026-09-11T05:29:02Z | |
| dc.date.available | 2026-09-11T05:29:02Z | |
| dc.date.issued | 2018 | |
| dc.description | Bikram Khadka Department of Biochemistry, Devdaha Medical College and Research Institute, Devdaha, Rupandehi, Nepal. Mohan Lal Tiwari Department of  Internal Medicine, Devdaha Medical College and Research Institute, Devdaha, Rupandehi, Nepal. Ravi Gautam Department of Occupational Health, College of Bio-Medical Sciences, Daegu Catholic University, Gyeongsan 38430, Korea Binod Timalsina Devdaha Medical College and Research Institute, Devdaha, Rupandehi, Nepal Nandu Prasad Pathak Internal Medicine, Lumbini Zonal Hospital, Rupandehi, Butwal, Nepal Krishna Kharel Department of Orthopedic Surgery, Tilottama Hospital, Rupandehi, Butwal, Nepal Shanta Sharma Deapartment of Community Medicine, Devdaha Medical College and Research Institute, Devdaha, Rupandehi, Nepal Dilaram Acharya Department of Community Medicine, Devdaha Medical College and Research Institute, Devdaha, Rupandehi, Nepal. | |
| dc.description.abstract | Abstract Introduction: Bone turnover leading to osteoporosis and poor quality of life is common during post-menopausal period. Study of bone turnover markers that contribute to non-invasive assessment of bone-metabolic disorders holds an important of research in low income country like Nepal. Methods: A hospital-based cross-sectional study conducted during the period of November 2016 to December 2017 among 354 women. Blood samples for calcium, inorganic phosphorus, alkaline phosphatase and vitamin D were collected and analyzed using a validated and calibrated tools. Data were analyzed using Statistical Package for the Social Sciences software version 20. Results: Mean±Standard deviation of age of post-menopausal women was significantly higher compared to pre-menopausal women (post-menopausal women, (57.98±8.08) vs. pre-menopausal, (31.35±5.83), (P<0.001). Selected biochemical markers of bone-turnover such as alkaline phosphatase levels were significantly higher with year since menopause (P<0.001), whereas serum calcium, and vitamin D were decreasing with year since menopause among post-menopausal women. In addition, calcium and vitamin D were significantly negatively correlated with year since menopause (P<0.01) while body mass index, inorganic phosphorus and alkaline phosphatase were significantly positively correlated with year since menopause (P<0.01). Conclusions: Our study revealed that body mass index, inorganic phosphorus and alkaline phosphatase positively correlated with year since menopause while calcium and vitamin D were negatively correlated suggesting for a medical supervision of hormonal changes and periodic dosing of calcium and vitamin D among post-menopausal women to reduce the problem of bone health. | |
| dc.identifier | https://doi.org/10.31729/jnma.3604 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14572/7641 | |
| dc.language.iso | en_US | |
| dc.publisher | Nepal Medical Association | |
| dc.title | Correlates of Selected Biochemical Markers of Bone turnover among Post-Menopausal Women | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| local.article.type | Original Article | |
| oaire.citation.endPage | 758 | |
| oaire.citation.startPage | 754 | |
| relation.isJournalIssueOfPublication | 308135e0-5068-4727-8b3a-37a74ffe96ca | |
| relation.isJournalIssueOfPublication.latestForDiscovery | 308135e0-5068-4727-8b3a-37a74ffe96ca | |
| relation.isJournalOfPublication | e6e146a0-0ece-4aba-aa0a-6ccfbd10a12a |