Article:
Diversity of hepatitis B genotypes in Nepal and updated phylogenetic tree: a pilot survey in 2012

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creativeworkseries.issnJNMA Print ISSN: 0028-2715; Online ISSN: 1815-672X
dc.contributor.authorPaudel, Damodar
dc.contributor.authorMyo Nein Aung
dc.contributor.authorPattaratida Sa-nguanmo
dc.contributor.authorSuvedi, Sushma
dc.contributor.authorPatel, Anuj
dc.contributor.authorSharma, Dipendra
dc.contributor.authorYong Poovorawan
dc.creator.affiliationMid-western regional police hospital, Nepalgunj, Nepal.
dc.creator.affiliationDepartment of Public Health, Juntendo University School of Medicine, Tokyo, Japan, Boromarajonani College of Nursing, Nakhon Lampang, Lampang, Thailand.
dc.creator.affiliationCenter of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Thailand.
dc.creator.affiliationNepalgunj Medical college, Nepalgunj, Nepal.
dc.creator.affiliationPrawash medical college, Palpa, Nepal.
dc.creator.affiliationSechenkaruna Hospital, Baudha, Kathmandu, Nepal.
dc.creator.affiliationCenter of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Thailand.
dc.date.accessioned2026-10-06T05:21:12Z
dc.date.available2026-10-06T05:21:12Z
dc.date.issued2014
dc.description.abstractAbstract Introduction: Hepatitis B virus is a current global health problem. HBV genotypes influence the treatment and long term outcome of HBV infected patients. Moreover, HBV genotypes differ in various region of the world. Such data was reported haphazardly but yet to be comprehensive for Nepal. This study attempted to find out the diverse hepatitis B genotypes in Nepal. Methods: A convenient serum sample of 58 HBsAg positive patients from different parts of the country mainly from Nepalgunj, Palpa and Kathmandu were screened for hepatitis B genotype. Sequencing was done and Phylogenetic tree was created. Results: Among 58 samples, 23 were genotype D, 17were genotype A and B wereC/D recombinant. Phylogenetic trees were created by distance-matrix and neighbor-joining analyses after bootstrapping to 1000 replicates. Discussion: HBV genotypes A and D are the most common genotype in Nepal. Horizontal transmission is common in these genotypes. C/D recombinant genotype may be transmitted from Tibetan people living in Kathmandu. Prophylactic major controlling, horizontal and cross border transmission could be effective. Conclusions: Three major genotypes of HBV in Nepal were found to be A, C and D. Despite being a low prevalence area, Nepal has a diversity of hepatitis B genotypes. Keywords: Genotypes; HBV; Nepal.
dc.identifier.doihttps://doi.org/10.31729/jnma.2799
dc.identifier.urihttps://hdl.handle.net/20.500.14572/7967
dc.language.isoen_US
dc.publisherNepal Medical Association
dc.subjectGenotypes
dc.subjectHBV
dc.subjectNepal
dc.titleDiversity of hepatitis B genotypes in Nepal and updated phylogenetic tree: a pilot survey in 2012
dc.typeArticle
dspace.entity.typePublication
local.article.typeOriginal Article
oaire.citation.endPage991
oaire.citation.startPage986
relation.isJournalIssueOfPublication52658252-c299-4e73-8477-994dfd16a0d2
relation.isJournalIssueOfPublication.latestForDiscovery52658252-c299-4e73-8477-994dfd16a0d2
relation.isJournalOfPublicatione6e146a0-0ece-4aba-aa0a-6ccfbd10a12a

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