Publication: Comparison of Intranasal Midazolam and Rectal Diazepam as Anticonvulsant in Children
Date
2015
Article Type
Original Article
Journal Title
Journal ISSN
ISSN 1990-7974 eISSN 1990-7982
Volume Title
Pages
Pages: 117 - 122
Publisher
Nepal Paediatric Society (JNPS)
Abstract
Abstract:
Introduction: Rectal diazepam is reputed as the gold-standard management of childhood seizures. Otherwise, intranasal (IN) midazolam has no first-pass metabolism and faster onset of action. The effectiveness and easier route of these drugs are important choices for faster seizure cessation. The aim of this study was to clarify the effectiveness of intranasal midazolam compared with rectal diazepam for seizure termination.
Material and Methods: The children, one month until 18 years of age, presented with acute seizures. Patients were randomly classified into two groups with either received intranasal midazolam or rectal diazepam for seizure termination. Interval time of drug administration to cease seizure was compared. The log-rank analysis was used for statistical analysis. Side effect of both drugs were evaluated.
Results: There were 60 patients enrolled the study, 30 in each group. The median time interval for seizures cessation with intranasal midazolam was 42 seconds, otherwise in rectal diazepam group was 180 seconds. There was statistically significant difference interval time between two groups (p<0.01). None of the both groups had any significant side effects statistically.
Conclusion: Intranasal midazolam is effective to terminate a seizure in children. It can be used as an alternative treatment for seizures in patients with intravenous or rectal route difficulties.
Description
Prastiya Indra Gunawan
Pediatric Neurology Airlangga University Surabaya
Fadil Rulian
Paediatric Neurology, Airlangga University Surabaya
Darto Saharso
Paediatric Neurology, Airlangga University Surabaya
Keywords
Seizures, Intranasal midazolam, Rectal diazepam, Children, Effective
Identifier
https://doi.org/10.3126/jnps.v35i2.13581