Risk-based Management of Non-muscle Invasive Bladder Cancer: Experience from Tribhuvan University Teaching Hospital

Luitel, BR; Chalise, PR; Sidharth; Gupta, DK; Subedi, P; Chapagain, S; Sharma, UK; Gyawali, PR; Shrestha, GK; Joshi, BR

Publication:
Risk-based Management of Non-muscle Invasive Bladder Cancer: Experience from Tribhuvan University Teaching Hospital

creativeworkseries.issn	1812-2027
dc.contributor.author	Luitel, BR
dc.contributor.author	Chalise, PR
dc.contributor.author	Sidharth
dc.contributor.author	Gupta, DK
dc.contributor.author	Subedi, P
dc.contributor.author	Chapagain, S
dc.contributor.author	Sharma, UK
dc.contributor.author	Gyawali, PR
dc.contributor.author	Shrestha, GK
dc.contributor.author	Joshi, BR
dc.date.accessioned	2025-10-16T08:09:50Z
dc.date.available	2025-10-16T08:09:50Z
dc.date.issued	2016
dc.description	Luitel BR, Chalise PR, Sidharth, Gupta DK, Subedi P, Chapagain S, Sharma UK, Gyawali PR, Shrestha GK, Joshi BR Department of Surgery, Urology Unit, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.
dc.description.abstract	ABSTRACT Background Most of the recent evidences suggest for risk-based management of non muscle invasive bladder cancer (NMIBC) to reduce the risk of recurrence and progression. Objective This study was conducted to assess the recurrence and progression of non muscle invasive bladder cancer in Nepalese patients using European Organization for Research and Treatment of Cancer (EORTC) risk tables and to assess the effectiveness of intravesical therapy to reduce the risk of recurrence. Method A prospective observational single centre study was conducted at Tribhuvan University Teaching Hospital from January 2010- December 2012. Forty six patients with non muscle invasive bladder cancer who underwent transurethral resection of bladder tumor and completed two years follow up were included. According to the European Organization for Research and Treatment of Cancer (EORTC) risk table, the patients were divided into low, intermediate and high risk groups. The patients received postoperative adjuvant therapy and surveillance as per the European Association of Urology guidelines. Result Among the 46 patients, the overall two year recurrence and progression rate was 8 (17%) and 1 (2%) respectively. Out of seven patients in low risk category, none of them developed recurrence or progression of disease. Out of 15 patients in intermediate risk category the one year and two year recurrence rate was 13% and 20% respectively. Out of 24 patients in high risk category the one and two year recurrence rate was 17% and 21% respectively. The risk reduction by use of intravesical Bacillus Calmette Guerin (BCG) for recurrence in high risk category was 58% and 60% in first and second year respectively. In our study, the overall and individual risk group, the one and two year recurrence rate was lower than that predicted by European Organization for Research and Treatment of Cancer risk table. Conclusion Risk-based management of non muscle invasive bladder cancer by using the European Organization for Research and Treatment of Cancer risk table is a useful method of management, though its prediction rates are lower in Nepalese population. KEY WORDS EORTC, intravesical therapy, NMIBC, progression, recurrence, risk table
dc.identifier.uri	https://hdl.handle.net/20.500.14572/2758
dc.language.iso	en_US
dc.publisher	Kathmandu University
dc.subject	EORTC
dc.subject	intravesical therapy
dc.subject	NMIBC
dc.subject	progression
dc.subject	recurrence
dc.subject	risk table
dc.title	Risk-based Management of Non-muscle Invasive Bladder Cancer: Experience from Tribhuvan University Teaching Hospital
dc.type	Article
dspace.entity.type	Publication
local.article.type	Original Article
oaire.citation.endPage	356
oaire.citation.startPage	352
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