Publication:
Association of Post-Operative Cardiac Enzyme Levels with Early Mortality Following Coronary Artery Bypass Grafting

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creativeworkseries.issn1999-6217
dc.contributor.authorKadel, Prashiddha Bikram
dc.contributor.authorBhattarai, Anil
dc.contributor.authorBaral, Ravi Kumar
dc.contributor.authorKhakural, Prabhat
dc.contributor.authorBashyal, Krishnaprasad
dc.contributor.authorThapa, Srijana
dc.date.accessioned2026-08-20T04:08:46Z
dc.date.available2026-08-20T04:08:46Z
dc.date.issued2026
dc.descriptionPrashiddha Bikram Kadel Department of Cardiothoracic and Vascular Surgery, Manmohan Cardiothoracic Vascular and Transplant Centre, Maharajgunj, Kathmandu, Nepal Anil Bhattarai Department of Cardiothoracic and Vascular Surgery, Manmohan Cardiothoracic Vascular and Transplant Centre, Maharajgunj, Kathmandu, Nepal Ravi Kumar Baral Department of Cardiothoracic and Vascular Surgery, Manmohan Cardiothoracic Vascular and Transplant Centre, Maharajgunj, Kathmandu, Nepal Prabhat Khakural Department of Cardiothoracic and Vascular Surgery, Manmohan Cardiothoracic Vascular and Transplant Centre, Maharajgunj, Kathmandu, Nepal Krishnaprasad Bashyal Kathmandu Medical College, Kathmandu, Nepal Srijana Thapa Department of Cardiothoracic and Vascular Surgery, Manmohan Cardiothoracic Vascular and Transplant Centre, Maharajgunj, Kathmandu, Nepal
dc.description.abstractAbstract: Background: Post-operative myocardial injury is an important determinant for mortality and morbidity following Coronary Artery Bypass Graft surgery. This study evaluated the role of serial post-operative cardiac biomarker and enzyme (CK-MB, Troponin I) measurement in predicting in-hospital mortality following CABG surgery. Methods: This retrospective study included patients undergoing CABG procedure at Manmohan Cardiothoracic Centre from January 2020 to January 2021. Cardiac Biomarkers (CK-MB and Troponin I) were measured at 6,12 and 24 hours post-operatively. The Mann–Whitney U test was used for comparison of biomarkers between survivors (n=40) and non-survivors (n=3). Receiver Operating Characteristic (ROC) curve analysis with Youden Index was used to determine optimal cutoffs values. Results: A total of 43 patients were enrolled in the study. In-hospital mortality was 7% (3/43) with 40 survivors and 3 non-survivors. No significant differences were observed in cardiac enzymes measured at 6 hours, between the survivors and non-survivors (Troponin I, p=0.206; CK-MB, p=0.391). However, biomarkers were significantly higher in non-survivors at 12 hours (Troponin I p=0.038; CK-MB p=0.004) and 24 hours (Troponin I p=0.007; CK-MB p=0.005). ROC demonstrated excellent predictive performance of CK-MB at 12 hours (AUC=1.00, cutoff at 146 IU/L, sensitivity 100%, specificity 100%), CK-MB at 24 hours (AUC =0.95, cutoff at 155 IU/L) and Troponin I at 24 hours (AUC=0.92, cutoff at 5.17ng/ml). However, these findings should be interpreted cautiously due to only three mortality events. Conclusions: Post operative Cardiac biomarkers (Troponin I >5.17 ng/ml at 24 hours and CK-MB >146 IU/L at 12 hours and >155 IU/L at 24 hours) were associated with in-hospital mortality following CABG and warrants further evaluation as a post-operative risk stratification marker. Keywords: Cardiac biomarkers; coronary artery bypass surgery; creatine kinase MB; myocardial injury; troponin I.
dc.identifierhttps://doi.org/10.33314/jnhrc.v24i01.5580
dc.identifier.urihttps://hdl.handle.net/20.500.14572/7370
dc.language.isoen_US
dc.publisherNepal Health Research Council
dc.subjectCardiac biomarkers
dc.subjectcoronary artery bypass surgery
dc.subjectcreatine kinase MB
dc.subjectmyocardial injury
dc.subjecttroponin I
dc.titleAssociation of Post-Operative Cardiac Enzyme Levels with Early Mortality Following Coronary Artery Bypass Grafting
dc.typeArticle
dspace.entity.typePublication
local.article.typeOriginal Article
oaire.citation.endPage172
oaire.citation.startPage167
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relation.isJournalIssueOfPublication.latestForDiscoverya1c63b20-6d6e-4473-9408-632d1b427f81
relation.isJournalOfPublication40bd2739-8b19-447c-be60-723a1bdd1dcd

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