Publication: Effectiveness of nicotinic acid and bezafibrate alone and in combination for reducing serum triglyceride level
| creativeworkseries.issn | 1812-2027 | |
| dc.contributor.author | B, Pradhan | |
| dc.contributor.author | A, Neopane | |
| dc.contributor.author | S, Karki | |
| dc.contributor.author | DB, Karki | |
| dc.date.accessioned | 2025-07-20T08:15:24Z | |
| dc.date.available | 2025-07-20T08:15:24Z | |
| dc.date.issued | 2005 | |
| dc.description.abstract | Objective: To study the effectiveness of nicotinic acid and Bezafibrate alone and in combination for reducing triglyceride level. Design: It was a randomised, prospective, longitudinal study. Setting: Patients attending a private clinic, and medical department of Kathmandu Medical College, Sinamangal. Methods: This study included 83 consecutive patients, 19 females and 64 males with hypertriglyceridaemia (defined as serum triglyceride >200mg/dl) attending the department of medicine, Kathmandu Medical College, Sinamangal and private clinic. Main outcome measures: Statistically significant reduction of serum triglyceride level. Result: 51 out of 83 patients completed the study in which Nicotinic acid alone reduced the serum trygleceride level from 320.62 ± 104.23 to 182.55 ± 46.21, which is a reduction of 138.07 ± 85.69 (P. value = 001). Bezafibrate when given alone also reduced triglyceride level significantly from 345.25 ± 181.03 to 203.30±93.59 which is a reduction of 141.95 ± 121.130 (P value= .001). When a combination of both drugs was given the reduction of 472.73±247.53 (P value =.002) was achieved. Conclusions: Nicotinic acid is a very effective drug in reducing serum triglyceride level and its effectiveness is similar to Bezafibrate. There is no added benefit of giving a combination of nicotinic acid and Bezafibrate in reducing serum triglyceride level. Keywords: Hypertriglyceridaemia, Nicotinic acid, Bezafibrate. Abbreviations: TG= Triglyceride, TC = Total cholesterol, HDL= High density lipoprotein, LDL= Low density lipoprotein NCEP-ATP III= National Cholesterol Education Programme-Adult Treatment panel 111 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14572/426 | |
| dc.language.iso | en_US | |
| dc.publisher | Kathmandu University | |
| dc.title | Effectiveness of nicotinic acid and bezafibrate alone and in combination for reducing serum triglyceride level | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| local.article.type | Original Article | |
| oaire.citation.endPage | 414 | |
| oaire.citation.startPage | 411 | |
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| relation.isJournalOfPublication | a782b7ff-cf89-4178-ad1c-11ed89cfe1bd |