Publication: Alteration of Thyroid Hormone among Patients with Ischemic Stroke visiting a Tertiary Care Hospital: A Descriptive Cross-sectional Study
Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Nepal Medical Association
Abstract
Abstract:
Introduction: Stroke is broadly classified as cerebral infarction, intracerebral hemorrhage and subarachnoid hemorrhage. Neuroendocrine proļ¬le is altered in acute ischemic stroke and there is a link between hypothyroidism and atherosclerosis which in turn may lead to stroke. The objective of this study was to find out the prevalence of alteration of thyroid hormones in patients with ischemic stroke in a tertiary care center.
Methods: This descriptive cross-sectional study was conducted from June to December 2019 in a tertiary care center. Ethical approval was taken from Institutional review board of National Academy of Medical Sciences (reference number: IM 175). Patients with a diagnosis of stroke, without evidence of cardioembolic source, history of liver disease, renal failure and thyroid disease and who do not use thyroidal supplementation within 180 days prior the event were included. Convenience sampling was done. Data was entered in Microsoft Excel and analyzed using Statistical Package for the Social Sciences version 22. Point estimate at 90% Confidence Interval was calculated along with frequency and percentage for binary data.
Results: The prevalence of altered thyroid levels among 73 patients was 13 (17.8%) (90% Confidence Interval= 10.44-25.16). Among them 11 (15.1%) were hypothyroid and 2 (2.7%) were hyperthyroid. Among severity of hypothyroid cases, subclinical hypothyroidism grade IA was seen in 51 (70%), subclinical hypothyroidism grade IB was seen in 22 (30%),
Conclusions: The prevalence of altered thyroid levels among patients undergoing ischemic stroke was similar to the findings of other international studies.
Description
Saroja Bashyal
Department of Internal Medicine, Rapti Provincial Hospital, Dang, Nepal
https://orcid.org/0000-0002-8561-5412
Manen Prasad Gorkhaly
Department of Internal Medicine, Bir Hospital, National Academy of Medical Sciences, Kathmandu, Nepal
Rameshwor Devkota
Deparment of Radiology, Rapti Provincial Hospital, Dang, Nepal
https://orcid.org/0000-0002-8561-5412
Ramila Devkota
Deparment of Radiology, Bir Hospital, National academy of Medical Sciences, Kathamndu, Nepal
Pradeep Raj Regmi
Deparment of Radiology, Hospital for Advanced Medicine and Surgery, Dhumbarahi, Kathmandu, Nepal
https://orcid.org/0000-0001-9571-9736
Isha Amatya
Department of Community Medicine, Kathmandu Medical College, Sinamangal, Kathmandu, Nepal
https://orcid.org/0000-0001-6778-8275
Keywords
hyperthyroidism, hypothyroidism, ischemic stroke