Publication: Prevalence of helicobacter pylori in Dhulikhel Hospital, Kathmandu University Teaching Hospital: A retrospective histopathologic study
Date
2005
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
Objective: The main objective of this study was to determine prevalence of Helicobacter pylori infection in
Dhulikhel Hospital, Kathmandu University Teaching Hospital.
Methodology: Endoscopic antral biopsies from January 1, 2004 to August 31, 2005 were studied retrospectively.
Hematoxylin and eosin and Giemsa stained histological sections were examined.
Results: Out of 224 patients (Male 125 and female 99) who underwent endoscopic biopsy and included in the study,
a total of 76 (33.9%) patients (Male 50 and female 26) were infected by H. pylori. The mean age of the H. pylori
infected patients was 40.2 years (SD 16.0). The infection by H. pylori was significantly higher in males than females
(p<0.05) with male to female ratio of 1.9:1. The most common (31.3%) histopathologic finding was chronic
superficial gastritis followed by normal histology (30.8%). A total of 10 cases (4.5%) of adenocarcinoma and 16
cases (7.1%) of intestinal metaplasia were detected and neither of them showed presence of H. pylori. Two cases
(0.9%) were diagnosed as suspected malignancy and both were negative for H. pylori infection. Among gastritis, H.
pylori was most frequently observed in chronic active gastritis (86.1%). Two of 69 cases (2.9%) of normal gastric
mucosa showed H. pylori.
Keywords: Helicobacter pylori, gastritis, endoscopy, prevalence, Nepal