Publication: Platelet aggregometric study on whole blood of patients with ischaemic heart disease
Date
2005
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
Platelet aggregation is an important in vitro test to assess platelet aggregation response in IHD. The present
prospective case control study was undertaken to evaluate the platelet aggregation response in IHD and the effects of
aspirin therapy on it. Platelet aggregation was conducted on whole blood by the Chrono- Log whole blood
Aggrometer model 540-VS. Various agonists used for platelet aggregation were collagen, ADP, Epinephrine and
Thrombin. High platelet aggregation was observed in-patients of IHD as compared to controls by few or all of the
reagents used. Platelet aggregation was high in both MI and angina as compared to control cases. However, cases of
MI showed higher response than those of angina. Aspirin intake was associated with a decrease in platelet
aggregation in patients of IHD. The platelet aggregation response was higher in PRP as compared to whole blood
with similar concentration of reagents, however whole blood was equally effective as PRP in detecting hyper-
responsive platelets in - patients of IHD.
Key words: Platelet aggregation, Ischaemic heart disease, chrono-log Aggrometer, platelet function.