Publication: Relation between gallbladder neoplasm and helicobacter hepaticus infection
| creativeworkseries.issn | 1812-2027 | |
| dc.contributor.author | Pradhan, SB | |
| dc.contributor.author | Dali, S | |
| dc.date.accessioned | 2025-07-16T06:26:32Z | |
| dc.date.available | 2025-07-16T06:26:32Z | |
| dc.date.issued | 2004 | |
| dc.description.abstract | Objective: The main objective of this study was to see the various histopathological changes in the gallbladder with cholelithiasis and to correlate them with Helicobacter hepaticus infection. Methods: A total of 380 cholecystectomy specimens were received during a study period from 2058/11/29 to 2059/11/4 at Department of Pathology, TU Teaching Hospital, Institute of Medicine. Results: Among 380 cases, 249 (65.53%) were found to have chronic cholecystitis, 52 (13.68%) cholesterolosis, 29 (7.63%) adenomyosis, 20 (5.26%) metaplasia, 15 (3.95%) low-grade dysplasia, 10(2.63%) malignancy, 4(1.05%) xanthogranulomatous change and 1(0.26%) carcinoma in situ. Out of these, 100 cases that were willing to provide gallbladder for study were taken as a study group. Sections were stained with Haematoxylin & Eosin for microscopic features and with Warthin Starry Silver stain for Helicobacter hepaticus. Among the study group, 43% cases were found to have chronic cholecystitis, 17% adenomyosis, 13% cholesterolosis, 9% low-grade dysplasia, 9% metaplasia, 7% malignancy, 1% carcinoma in situ and 1% xanthogranulomatous change. All the malignant cases were found to be Adenocarcinoma. Out of total 100 cases, 82% cases were found to have Helicobacter hepaticus infection. Only one out of 7 malignant cases (14.29%) was found to be negative for Helicobacter Hepaticus infection. Gallbladder neoplasm was found to be common in Nepal comprising 2.63%. Helicobacter hepaticus infection was found in 82% of gallbladders and it was found in 87.5% of malignant cases. Whether Helicobacter hepaticus that might be the number one cause for the gallstone formation that ultimately leads to malignancy or itself acts as a risk factor for the pathogenesis of carcinoma gallbladder is yet to be determined. Key words: Helicobacter hepaticus, Helicobacter pylori, Warthin Starry Silver stain | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14572/264 | |
| dc.language.iso | en_US | |
| dc.publisher | Kathmandu University | |
| dc.title | Relation between gallbladder neoplasm and helicobacter hepaticus infection | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| local.article.type | Original Article | |
| oaire.citation.endPage | 335 | |
| oaire.citation.startPage | 331 | |
| relation.isJournalIssueOfPublication | 75b91ce1-12b4-49f9-83e0-011a3de4c9fb | |
| relation.isJournalIssueOfPublication.latestForDiscovery | 75b91ce1-12b4-49f9-83e0-011a3de4c9fb | |
| relation.isJournalOfPublication | a782b7ff-cf89-4178-ad1c-11ed89cfe1bd |