Publication: Etoricoxib Induced Toxic Epidermal Necrolysis in a case of Systemic Lupus Erythematosus: A Case Report
Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Nepal Medical Association
Abstract
Abstract
Toxic epidermal necrolysis is a potentially life-threatening dermatological condition whose pathogenesis and exact treatment are not yet known. Drugs like anticonvulsants, allopurinol and non-steroidal anti-inflammatory drugs like etoricoxib, a selective cyclo-oxygenase-2 inhibitor prescribed for pain management are associated with a high risk of toxic epidermal necrolysis. It is also associated with immunodeficiency and dysregulated immune reactions like systemic lupus erythematosus, an autoimmune disease in which organs and cells undergo damage initially mediated by tissue binding auto-antibodies and immune complexes. Here, a 34 year old lady was presented in emergency with multiple maculopapular rashes over the neck and trunk region after treatment with etoricoxib for osteoarthritis of the left foot.
Description
Asim Pandey
Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal
Samriddhi Parajuli
Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal
Alok Dhungel
Department of Internal Medicine, Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal
Rahul Devkota
Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal
Angel Dongol
Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal
Keywords
Case reports, Etoricoxib, Systemic lupus erythematosus, Toxic epidermal Necrolysis