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Effectiveness of Lower Range of High-intensity Statin Therapy in Lowering LDL-C among STEMI Patients

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creativeworkseries.issn1999-6217
dc.contributor.authorPrajapati, Dipanker
dc.contributor.authorAdhikari, Chandra Mani
dc.contributor.authorTimalsena, Birat Krishna
dc.contributor.authorMaharjan, Nira Shrestha
dc.contributor.authorDhital, Rolina
dc.contributor.authorKhatri, Anjali
dc.contributor.authorBogati, Amrit
dc.contributor.authorManandhar, Reeju
dc.contributor.authorDhungana, Murari
dc.contributor.authorSafi, Md. Sajjad
dc.contributor.authorKhan, Barkadin
dc.contributor.authorGhimire, Vijay
dc.contributor.authorRoy, Rahul
dc.contributor.authorAdhikari, Puja
dc.contributor.authorDhungana, Suraksha
dc.contributor.authorRajbhandari, Sujeeb
dc.date.accessioned2025-07-20T07:16:45Z
dc.date.available2025-07-20T07:16:45Z
dc.date.issued2024
dc.descriptionDipanker Prajapati Department of Cardiology, Shahid Gangalal National Heart Centre Chandra Mani Adhikari Department of Cardiology, Shahid Gangalal National Heart Centre Birat Krishna Timalsena Department of Cardiology, Shahid Gangalal National Heart Centre Nira Shrestha Maharjan Department of Nursing, Shahid Gangalal National Heart Centre Rolina Dhital Health Action and Research, Kathmandu, Nepal Anjali Khatri Department of Nursing, Shahid Gangalal National Heart Centre Amrit Bogati Department of Cardiology, Shahid Gangalal National Heart Centre Reeju Manandhar Department of Cardiology, Shahid Gangalal National Heart Centre Murari Dhungana Department of Cardiology, Shahid Gangalal National Heart Centre Md. Sajjad Safi Department of Cardiology, Shahid Gangalal National Heart Centre Barkadin Khan Department of Cardiology, Shahid Gangalal National Heart Centre Vijay Ghimire Department of Cardiology, Shahid Gangalal National Heart Centre Rahul Roy Department of Cardiology, Shahid Gangalal National Heart Centre Puja Adhikari Department of Cardiology, Shahid Gangalal National Heart Centre Suraksha Dhungana Department of Nursing, Shahid Gangalal National Heart Centre Sujeeb Rajbhandari Department of Cardiology, Shahid Gangalal National Heart Centre
dc.description.abstractBackground: Lipid-lowering is an important intervention to reduce cardiovascular morbidity and mortality after ST-Elevation myocardial infarction. This study aimed to assess the proportion of such patients achieving guideline-directed therapeutic low-density lipoprotein cholesterol targets while on lower-range high-intensity statin treatment. Methods: This is a cross-sectional study conducted in Shahid Gangalal National Heart Centre, a tertiary cardiac center in Kathmandu, Nepal, from November 2021 to July 2022 among admitted acute ST-Elevation myocardial infarction patients who were prescribed a lower range of high-intensity statin therapy, Atorvastatin 40mg and Rosuvastatin 20 mg. Clinical characteristics were collected, including lipid parameters at baseline during admission and three months after the treatment. The proportion attaining the guideline-recommended levels was calculated and compared between each statin group. Results: A total of 240 patients were included in this study. The target low-density lipoprotein cholesterol level of less than 1.4mmol/L was noted only in 16.3% and the target reduction by ?50% from baseline only in 7.1%. Just 3.3 % achieved a target of <1.4 mmol/L and ?50% reduction from baseline. However, 40.8% of the participants in our study met the 2012 European Society of Cardiology guidelines’ target achievement of less than 1.8 mmol/L. Conclusions: The overall proportion of patients attaining recommended low-density lipoprotein cholesterol levels after recent ST-Elevation myocardial infarction was low when patients were prescribed with a lower range of high-intensity statin, reflecting the need for rigorous follow up including monitoring of lipid levels and intensification of statin dose and type as recommended by international guidelines. Keywords: Low-Density Lipoprotein Cholesterol; secondary prevention; statin; statin intensity; ST-Elevation myocardial infarction.
dc.identifierhttps://doi.org/10.33314/jnhrc.v22i03.4886
dc.identifier.urihttps://hdl.handle.net/20.500.14572/399
dc.language.isoen_US
dc.publisherNepal Health Research Council
dc.titleEffectiveness of Lower Range of High-intensity Statin Therapy in Lowering LDL-C among STEMI Patients
dc.typeArticle
dspace.entity.typePublication
local.article.typeOriginal Article
oaire.citation.endPage518
oaire.citation.startPage509
relation.isJournalIssueOfPublicationbdc38a4e-8fed-4c8d-ae10-a4918d68512e
relation.isJournalIssueOfPublication.latestForDiscoverybdc38a4e-8fed-4c8d-ae10-a4918d68512e
relation.isJournalOfPublication40bd2739-8b19-447c-be60-723a1bdd1dcd

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