Article:
Effect of dexamethasone and pheniramine maleate in patients undergoing elective laparoscopic cholecystectomy

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creativeworkseries.issnJNMA Print ISSN: 0028-2715; Online ISSN: 1815-672X
dc.contributor.authorShrestha, Binod Bade
dc.contributor.authorKarmacharya, Mikesh
dc.contributor.authorGharti, Binod Babu
dc.contributor.authorTimilsina, Bishowdeep
dc.contributor.authorGhimire, Pradeep
dc.creator.affiliationManipal College of Medical Sciences, phulbari-11, Kaski, pokhara, Nepal.
dc.creator.affiliationDepartment of Surgery, Manipal College of Medical Sciences, Kaski, Pokhara, Nepal.
dc.creator.affiliationDepartment of Surgery, Manipal College of Medical Sciences, Kaski, Pokhara, Nepal.
dc.creator.affiliationDepartment of Surgery, Manipal College of Medical Sciences, Kaski, Pokhara, Nepal.
dc.creator.affiliationDepartment of Surgery, Manipal College of Medical Sciences, Kaski, Pokhara, Nepal.
dc.date.accessioned2026-10-07T06:22:08Z
dc.date.available2026-10-07T06:22:08Z
dc.date.issued2014
dc.description.abstractAbstract Introduction: Laparoscopic cholecystectomy is elective surgical procedure for uncomplicated gallstone disease and gallbladder polyp. The objective of this study was to assess the efficacy of Dexamethasone and Pheniramine hydrogen maleate on reducing stress response and pain after surgery in patients undergoing laparoscopic cholecystectomy. Methods: After obtaining approval from the institutional ethics committee and written informed consent, 120 patients undergoing elective laparoscopic cholecystectomy were enrolled in the study from Sep 2103 to Aug 2014 at Department of Surgery, Manipal College of Medical Sciences, Pokhara, Nepal. Patients were randomized to receive either 8mg/2ml of Dexamethasone + 45.5/2ml Pheniramine hydrogen maleate (treatment group, n= 60) or 5 ml of normal saline (control group, n=60) 90 minutes before skin incision. Results: There was a reduction of total bilirubin, C-reactive protein value and Visual Analogue Score (VAS) in treatment group as compared to control group (p <0.05). Conclusions: Use of Dexamethasone and Pheniramine hydrogen maleate prior to surgical skin incision helps to reduce both postoperative pain and acute physiological stress. Keywords: C - reactive protein; Dexamethasone; Laparoscopic cholecystectomy; Pheniramine hydrogen maleate.
dc.identifier.doihttps://doi.org/10.31729/jnma.2717
dc.identifier.urihttps://hdl.handle.net/20.500.14572/8001
dc.language.isoen_US
dc.publisherNepal Medical Association
dc.subjectC - reactive protein
dc.subjectDexamethasone
dc.subjectLaparoscopic cholecystectomy
dc.subjectPheniramine hydrogen maleate
dc.titleEffect of dexamethasone and pheniramine maleate in patients undergoing elective laparoscopic cholecystectomy
dc.typeArticle
dspace.entity.typePublication
local.article.typeOriginal Article
oaire.citation.endPage924
oaire.citation.startPage920
relation.isJournalIssueOfPublication4f1bcc5a-e56f-4a48-86af-c28ab782631f
relation.isJournalIssueOfPublication.latestForDiscovery4f1bcc5a-e56f-4a48-86af-c28ab782631f
relation.isJournalOfPublicatione6e146a0-0ece-4aba-aa0a-6ccfbd10a12a

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