Publication: Combination of Alarm-intervention and Reboxetine in Therapy- Resistant Enuresis
Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
Nepal Paediatric Society (JNPS)
Abstract
Abstract:
Introduction: The first-line treatments of primary monosymptomatic night enuresis (PMNE) are alarm intervention and desmopressin. Some patients are resistant to these modes of treatment. Therefore Reboxetine has been used to treat PMNE in these scenarios in recent years and published in many studies. The aim of the study was to determine effectiveness and safety of combination of Alarm intervention and Reboxetine, to treat patients with therapyresistant enuresis.
Material and Methods: Two hundred and nineteen children of both sexes were participated in the experiment (average age, 11.3 years). Participants were divided into three groups: Group A (71 patients, Alarm intervention), Group B (79 patients, Reboxetine as monotherapy), Group C (69 patients, Alarm intervention + Reboxetine). The duration of treatment was twelve weeks, followed by follow-up period of twelve weeks to see efficacy.
Result: There was no significant change in number of enuresis episodes per week before and after treatment in a group B. The number of enuresis episodes per a week (weekly) in a group C reached: before treatment 5.3 (1.5), after treatment 1.0 (0.8), 3 three months after the end of treatment 0.7 (0.7). The percentage of patients with PMNE in a group C was significantly less immediately after the course of treatment (17.4%), and three months after treatment (24.6%).
Conclusion: Combined treatment of therapy-resistant enuresis with use of Alarm Intervention and Reboxetine gives a high percentage of cured patients both immediately after therapy (82.6%) and three months after the end (75.4%).
Description
Kirill Kosilov
Professor of Department of Social Sciences, School of Humanities, Far Eastern Federal University, and Professor of Department of Fundamental Medicine, School of Biomedicine, Far Eastern Federal University
Irina Kuzina
Head of the Department of Social Science, Far Eastern Federal University
Yuliya Gainullina
Professor of Department of Social Sciences, School of Humanities, Far Eastern Federal University
Vladimir Kuznetsov
Head of Department of Public Health of the Pacific State Medical University
Liliya Kosilova
Doctor in the Department of Functional Diagnostics
Elena Viktorovna Karashchuk
Department of Public Health, Pacific Medical University
Alexandra Prokofyeva
Leading specialist of the Department of Social Sciences Far Eastern Federal University
Sergay Loparev
Department of Urology, City polyclinic No 3
Keywords
Alarm intervention, Children and adolescents, Reboxetine