Publication:
Seroprevalence of Scrub Typhus in Patients Attending Dhulikhel Hospital, Kavre

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creativeworkseries.issn1812-2027
dc.contributor.authorMadhup, SK
dc.contributor.authorShrestha, R
dc.contributor.authorKatuwal, N
dc.contributor.authorMagar, SR
dc.contributor.authorShrestha, S
dc.contributor.authorBhandari, S
dc.contributor.authorTamrakar, D
dc.date.accessioned2025-12-21T06:50:46Z
dc.date.available2025-12-21T06:50:46Z
dc.date.issued2021
dc.descriptionMadhup SK,1Shrestha R,2,3Katuwal N,3 Magar SR,1 Shrestha S,1 Bhandari S,1 Tamrakar D3,4 1Department of Microbiology 2Department of Pharmacology 3Research and Development Division 4Department of Community Medicine Kathmandu University School of Medical Sciences Dhulikhel, Kavre, Nepal
dc.description.abstractABSTRACT Background Scrub typhus is a largely ignored tropical disease and a leading cause of undifferentiated febrile illness. It is caused by Orientia tsutsugamushi. Scrub Typhus is frequently observed in South Asian countries. However, clear epidemiological information of this disease is lacking in case of Nepal. Nepal has shown steady increase in cases of Scrub Typhus since 2015. The epidemiological data related to this disease would support the decision making and surveillance design for early outbreak detection and immediate responses including prevention and treatment of scrub typhus in Nepal. Objective To understand prevalence of Scrub Typhus in subjects who had visited outpatient department at Dhulikhel Hospital. Method In this study, we have studied antibody test data (n=784) for Scrub Typhus from 2019 to 2021. The tests were performed on serum samples of patients who had visited OPD at Dhulikhel Hospital with fever lasting more than 5 days. The kit used in analysis was Scrub Typhus Detect™ IgM ELISA Kit from InBios International. Result Out of the total subjects (n=784), 133 were positive (16.9%) for IgM antibody of Scrub Typhus. The positivity in female (18.6%) was higher than the male subjects (15.3%). The positivity rate was variable among the different age groups, with highest positivity for age group 0-14 years (25%). The seasonal variation was also observed among the seropositive cases. Conclusion Scrub Typhus being a neglected tropical disease has high prevalence. It can be postulated that female subjects and subjects of age group 0-14 years are vulnerable to the infection with Scrub Typhus. There is need to increase the surveillance of Scrub Typhus to add the knowledge for diagnosis and treatment. KEY WORDS ELISA, IgM, Scrub Typhus, Seroprevalence
dc.identifier.urihttps://hdl.handle.net/20.500.14572/3735
dc.language.isoen_US
dc.publisherKathmandu University
dc.subjectELISA
dc.subjectIgM
dc.subjectScrub Typhus
dc.subjectSeroprevalence
dc.titleSeroprevalence of Scrub Typhus in Patients Attending Dhulikhel Hospital, Kavre
dc.typeArticle
dspace.entity.typePublication
local.article.typeOriginal Article
oaire.citation.endPage498
oaire.citation.startPage494
relation.isJournalIssueOfPublication15eeb083-e217-49bb-bea1-16142e5271e1
relation.isJournalIssueOfPublication.latestForDiscovery15eeb083-e217-49bb-bea1-16142e5271e1
relation.isJournalOfPublicationa782b7ff-cf89-4178-ad1c-11ed89cfe1bd

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