Publication:
Extended Spectrum β-lactamase (ESBL) Producing Multi Drug Resistant (MDR) Urinary Pathogens in a Children Hospital from Nepal

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creativeworkseries.issn1812-2027
dc.contributor.authorSharma, KR
dc.contributor.authorBhandari, P
dc.contributor.authorAdhikari, N
dc.contributor.authorTripathi, P
dc.contributor.authorKhanal, S
dc.contributor.authorTiwari, BR
dc.date.accessioned2025-11-21T06:40:31Z
dc.date.available2025-11-21T06:40:31Z
dc.date.issued2018
dc.descriptionSharma KR,1 Bhandari P,2 Adhikari N,1 Tripathi P,3 Khanal S,2 Tiwari BR4 1Department of Microbiology, Kantipur College of Medical Sciences, Kathmandu, Nepal. 2Department of Microbiology, National College (NIST), Kathmandu, Nepal. 3Department of Pathology Laboratory, Kanti Children’s Hospital, Kathmandu, Nepal. 4School of Health and Allied Sciences, Pokhara University, Pokhara, Nepal
dc.description.abstractABSTRACT Background Multidrug resistant in clinical bacterial isolates has increasingly been reported through out the world and is associated with high morbidity, mortality and increased health care costs. It is important to determine the status of multidrug resistance pattern to understand the current resistance trend so that appropriate antibiotics can be used in practice. Objective To determine the antibiotic resistant profile and prevalence of extended spectrum β-lactamase producing multidrug resistant strains in pediatric patients of Kanti Children’s Hospital, Kathmandu, Nepal. Method Urine sample was cultured by standard microbiological techniques and bacterial isolates were identified using different biochemical tests. Antibiotic susceptibility testing was performed by Kirby Bauer disc diffusion method and extended spectrum β-lactamase detection was carried out using combined disc method as recommended by Clinical Laboratory Standard Institute guidelines. Result All together 65 different bacteria were isolated and subsequently identified. E. coli was the most common isolate with 46 (71%) isolates 63% of these isolates were multidrug resistant. Gram negative isolates were most resistant to nalidixic acid (81.97%) followed by ampicillin (69.35%) and co-trimoxazole (69.35%). The extended spectrum β-lactamase producing isolates were 43% among total isolates. Conclusion Higher rate of Extended Spectrum β-lactamase production among multidrug resistant isolates suggested routine extended spectrum β-lactamase testing in clinical isolates. KEY WORDS Antimicrobial, Multidrug resistant, Urinary tract infection
dc.identifier.urihttps://hdl.handle.net/20.500.14572/3205
dc.language.isoen_US
dc.publisherKathmandu University
dc.subjectAntimicrobial
dc.subjectMultidrug resistant
dc.subjectUrinary tract infection
dc.titleExtended Spectrum β-lactamase (ESBL) Producing Multi Drug Resistant (MDR) Urinary Pathogens in a Children Hospital from Nepal
dc.typeArticle
dspace.entity.typePublication
local.article.typeOriginal Article
oaire.citation.endPage155
oaire.citation.startPage151
relation.isJournalIssueOfPublication9413a8eb-6c9b-4953-b728-96cdafea83bb
relation.isJournalIssueOfPublication.latestForDiscovery9413a8eb-6c9b-4953-b728-96cdafea83bb
relation.isJournalOfPublicationa782b7ff-cf89-4178-ad1c-11ed89cfe1bd

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