Publication: Fulminant Hepatic Failure Due to Dengue
Date
2011
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT:
Dengue Fever (DF) is only rarely considered as a cause of acute liver failure even
globally and only a few case reports of acute hepatic failure and encephalopathy
occurring in DF in adults are available. We report a case of Acute Liver Failure due
to Dengue during a major outbreak in 2010 in Chitwan.
A 20 year old previously healthy female presented to the emergency department of
Chitwan Medical College with fever, jaundice and altered sensorium. She was tested
positive for Dengue IgM. Her biochemical and clinical parameters were suggestive
of acute liver failure with total billirubin of 10.1 mg/dL, direct billirubin of 5.2 mg/
dL, ALT 5760 IU, AST 14100 IU, alkaline phosphatase of 1250 IU, PT INR of 1.76 and
platelet count of 30,000 /mm3. Other causes for acute hepatic failure like acute viral
hepatitis, leptospirosis, malaria, Reye’s syndrome were ruled out. The patient was
admitted and managed in the ICU with supportive care and platelet transfusion.
With treatment she made a significant clinical and biochemical improvement
with AST of 105 IU, ALT of 120 IU and platelet count of 150,000/mm3. She was
discharged after 11 days of hospital stay.
KEY WORDS
Dengue, Dengue Hemorrhagic Fever, Fuminant Hepatic failure
Description
Sedhain A, Adhikari S, Regmi S, Chaudhari SK, Shah M, Shrestha B
Department of Medicine Chitwan Medical College Bharatpur, Chitwan Nepal.