Browsing by Author "Neupane, Saraswoti"
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Publication An Observational Study to Evaluate Quality of Life in Patients with Melasma in A Tertiary Level Hospital of Pokhara(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2021) Pudasaini, Prajwal; Neupane, SaraswotiAbstract: Introduction: Melasma is an acquired hyper melanosis that becomes more pronounced after sun exposure. Centro facial which is the commonest pattern followed by Malar and Mandibular are three clinical patterns of Melasma. Genetic influences, exposure to UV radiation, pregnancy, hormonal therapies, contribute to the pathogenesis of melasma. Melasma may considerably have significant effect on quality of life of patients. Objectives: The present study was conducted to evaluate the effects of melasma in quality of life (QoL) in the form of DLQI (Dermatology Life Quality Index) and severity of melasma according to Melasma Area and Severity Index (MASI). Materials and Methods: This is a hospital based cross-sectional prospective study conducted in 193 Melasma patients in the Department of Dermatology, Venereology and Leprology, Gandaki Medical College and Teaching Hospital, Pokhara from November 2018 to November 2019. MASI score was calculated and the patients were provided with a Nepali version of DLQI to fill up. Results: This study included 193 patients. Mean age of patients with melasma was 29.4 ± 8.5 years with maximum reported age of 59 years. The Mean age of onset of disease was 26.5 years. The Mean age of onset of disease had little impact on DLQI. The mean DLQI score was 10.9 ± 5.9, thus indicating “very large effect on patient’s life”. The mean MASI score was 6.6 ± 5.2. It was found that there was no correlation between severity of disease and DLQI scores (p=0.317) Conclusion: Melasma commonly affected females during second and third decades of life. It had a very large effect on patient’s life as assessed by DLQI. Keywords: Melanosis, Quality of Life, Severity of Illness Index, Ultraviolet RaysPublication Association between Acne and Body Mass Index: A Hospital Based Cross Sectional Study(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2018) Neupane, Saraswoti; Basnet, Binamra; Sharma, Tara DeviAbstract: Introduction: Acne vulgaris is a common and chronic inflammatory skin disease of pilosebaceous unit. Obesity is one of the biggest problems in western life style but nowadays, the problem is increasing even in low and middle-income countries. Body Mass Index (BMI) is used to accurately measure obesity. Objective: To find out the association between different categories of BMI and severity of acne. Materials and methods: This was a cross sectional prospective study conducted in the outpatient department of Gandaki Medical College from January to July, 2017. All the newly diagnosed patients with acne were included in the study. Height and weight of the patients was recorded and BMI was calculated. BMI was categorized as underweight, normal weight, overweight and obese. Type of lesions were noted and severity of acne was graded from 1 to 4. Statistical analysis was performed using SPSS version 17.0 for windows. One-way Analysis of Variance between groups (ANOVA) test was applied. P value of less than 0.05 was considered significant. Results: There were altogether 249 patients with acne. Age of the patients ranged from 10 to 44 years with mean age of 20.82 ±5.9 years. Most of the patients were in the age group of 11-20 years. Female: male ratio was 1:1.4. Majority of patients (65.5%) had normal BMI. Most of the patients had Grade 2 acne (52.6%). There was no significant association between the BMI and severity of acne (p=0.129). Conclusion: There was no significant association between BMI and severity of acne. Keywords: Acne vulgaris, comedones, hyperandrogenism, nodules, obesity, overweightPublication Congenital Syphilis: A Case Report(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2020) Subedi, Saujan; Jwarchan, Jayanti; Pandit, Shashwata Raj; Neupane, SaraswotiAbstract: Congenital syphilis is a chronic infectious disease caused by Treponema pallidum, a spirochete acquired in-utero by the fetus. Syphilis continues to affect pregnant population, in spite of various measures to control. Here we report a case of congenital syphilis in a two-year-old male child. Keywords: Penicillins, Spirochaetales, Syphilis, Congenital, Treponema pallidumPublication Cutaneous Leishmaniasis: Revisited(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2018) Neupane, SaraswotiNAPublication Dermatological Practice in Nepal during COVID-19 Crisis: Recommendations of National Panel of Experts(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2020) Parajuli, Sudip; Pokhrel, Dinesh Binod; Agrawal, Sudha; Kumar, Ajay; Pokhrel, Kumar; Bastola, Anup; Bhattarai, Sabeena; Shrestha, Shristi; Shrestha, Manisha; KC, Shekhar; Joshi, Smita; Das, Anil Kumar; Shah, Mahesh; Joshi, Shambhu Dutta; Paudel, Sushil; Hirachan, Shashi; Paudel, Upama; Neupane, SaraswotiAbstract: Introduction: Novel Coronavirus disease has caused a substantial halt to the ongoing world in every aspect. There are medical and social implications of the disease. Cutaneous manifestations have been reported to be a part of the disease as well. Dermatologists globally are in dilemma with the clinical practice because of the fear of acquiring the disease. Objectives: This article aims to recommend best practice measures that can be followed in local scenario for re-opening up of dermatological services in the context of Nepal. Materials and Methods: A preliminary draft for guidance on Dermatological services based on recommendations of American Academy of Dermatology, International league of Dermatological societies, National recommendations from Ministry of Health, Nepal was sent to a panel of national experts to determine the level of consensus in first week of April, 2020. A preliminary survey was sent to all the members of Society of Dermatologists, Venereologists, and leprologists of Nepal on first week of June and a second draft was subsequently formed which was sent again to experts and revised based on the opinions of national experts. Results: A total of 19 experts participated in the preparation of draft and reached a national consensus after a series of revisions in preliminary draft. Conclusion: Agreements regarding the opening of practice in dermatology discipline have been summarized. Recommendations have been made for opening of dermatological services – opening of outpatient department, performing dermatosurgical and cosmetic procedures as well as strategies on triage of patients and use of masks. Keywords: Coronavirus, Dermatology, Disease, NepalPublication Mucocutaneous Adverse Effects of Methotrexate Toxicity: A Case Series(Nepal Medical Association, 2025) Subedi, Bibek; Neupane, Saraswoti; Bhandari, Sajana; Timilsina, Sunil; Pokhrel, SudarshanAbstract Methotrexate is a widely used medication in dermatology, rheumatology, and oncology. However, patient misunderstandings or attempts to expedite symptom relief can lead to overuse, resulting in severe toxicity. This case series presents five instances of methotrexate toxicity due to daily dosing and excessive use for underlying disorders. All patients exhibited fever, skin, and mucosal lesions, alongside abnormal hematological parameters. Management involved immediate cessation of methotrexate, administration of leucovorin rescue therapy, and supportive care. Three patients fully recovered with the resolution of lesions and improved hematological profiles, while two succumbed to the illness. These cases underscore the critical need for early recognition of methotrexate toxicity symptoms and comprehensive patient counseling on proper dosing schedules to prevent such adverse outcomes.Publication Scrub Typhus in Western Nepal: A Series of Case Reports(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2020) Pudasaini, Prajwal; Ranjit, Annu; Neupane, SaraswotiAbstract: Scrub typhus, a mite borne infectious disease which is transmitted to humans by bite of trombiculid mite. An eschar, which is a characteristic necrotic skin lesion, is formed at the site of bite. Systemic spread via the hematogenous and lymphatic routes occur and the infected people develop fever, cutaneous rash, myalgia, and lymphadenopathy. Diagnosis of scrub typhus is often difficult because of vast variability and non-specific presentation of the disease. Scrub typhus has been poorly reported from Kaski district. Here we report series of five cases of scrub typhus from Kaski distrist of Western Nepal. Keywords: Nepal, Orientia tsutsugamushi, Scrub Typhus, TrombiculidaePublication Spectrum of Dermatological Manifestations among Travelers Presenting at aTravel Medicine Center in Western Nepal(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2019) Gupta, Sandeep; Pokhrel, Saroj; Neupane, Saraswoti; Pandey, PrativaAbstract: Introduction: Skin disorders are among the most common reasons for travelers to seek medical care during and after travel. There is limited data on the spectrum of dermatoses reported among travelers during travel especially in South Asian continent. Objective: To review the spectrum of skin disorder manifested among the traveler population attending a travel medicine hospital in western Nepal. Materials and Methods: We performed a prospective study of the travelers visiting The Canadian International Water and Energy Consultants (CIWEC) Hospital, and Travel Medicine Center in Pokhara with history of skin disorders. This study was done from September 2014 until December 2015. Results: A total of 130 (14.7%) patients presenting with dermatological manifestations were enrolled in the study. The most common diagnoses were bacterial skin infections 0.4%, arthropod bites 3.6% followed by animal bites and skin laceration due to trauma,each were 12.1%. Among patients with bacterial skin and soft tissue infections, pus culture and sensitivity were recorded in 13 patients. In almost fifty percent of our sample Staphylococcus aureus growth was seen, of which 38.5% were Methicillin Resistant Staphylococcus aureus. Conclusion: Bacterial skin and soft tissue infections, arthropod bites and animal bites were common reasons for travelers to seek medical consultations during travel in Nepal. This information will be useful for the medicine professionals while taking care of travelers and also while providing pre-travel consultation to the prospective travelers. Keywords: Nepal, Skin diseases, Staphylococcus aureus, Travel medicinePublication The Challenges of COVID-19 in Medical Education in Nepal(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2021) Paudel, Vikash; Neupane, SaraswotiAbstract: The Coronavirus Disease-2019 (COVID-19) pandemic has caused an unparalleled disruption in all forms of scientific learning process including medical education. It has presented a challenge for scientists, educators, and students.Widespread interruptions to medical education, scientific discussions, conference, and seminars have also been seen at times of major conflicts and pandemics in the past as well, which resulted in major changes in medical curriculum. This editorial discusses the medical education and how COVID-19 has affected medical education in Nepal. Besides, it also explores the potential implications of COVID-19 for the future of medical education. Keywords: COVID-19, Education, Medical, Pandemics, NepalPublication Topical Corticosteroids Misuse: A Burning Issue(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2019) Neupane, SaraswotiAbstract: Since the introduction of hydrocortisone into dermatology, a tremendous development has occurred in the field of topical corticosteroids. With the growing use of topical corticosteroids, a serious concern for its misuse is to be highlighted. This matter is of a great concern. Proper guidelines and legislation on the use of topical corticosteroids are warranted to combat this serious issue. Keywords: Glucocorticoids, Hydrocortisone, Nepal, Nonprescription drugs