Browsing by Author "Pandey, S"
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Publication Assessment of Therapeutic Efficacy of Anti-Malarial Drugs Against Uncomplicated Plasmodium Falciparum Malaria in the Indo-Nepal Border Jhapa District (Nepal) & Darjeeling District, West Bengal (India)(Nepal Health Research Council, 2003) Pandey, S; Ansari, M A; Valecha, N; Chand, P B; Wijeyaratne, P; Bista, M BPublication Comparison of Reverse Sural Artery Fasciocutaneous Flap in Soft Tissue Reconstruction Between above Ankle and Below Ankle Defect(Kathmandu University, 2022) Pandey, S; Bidary, SABSTRACT Background Fasciocutaneous reverse sural artery flap is a popular option to treat soft tissue defects in the distal leg, ankle, and foot region. Objective To compare the results of sural artery flap reconstruction between the above ankle and below ankle soft tissue defect. Method It was a retrospective study of sural flap reconstruction of varied etiology for the defect grouped as above ankle and below ankle operated over a period of five years. Flap and graft take-up, rate of primary healing, margin necrosis, and complications were the assessed outcome variables. Result There were a total of 37 patients, 17 cases of the above ankle and 20 cases of below ankle sural flap reconstruction analyzed in the study. Road traffic accident was the most common cause and the mean size of the defect was 40.70 cm2. The overall flap take-up rate was 94.6%, partial margin necrosis was in 6 patients, and > 50% flap necrosis was in 2 cases. The rate of primary healing, margin necrosis and mean healing time were 17 (100%) vs 12 (60%), 0 vs 8 cases (6 margin necrosis and 2 cases of > 50% of flap necrosis), and 20.04 days vs 22.50 days respectively in the above ankle and below ankle flap reconstruction groups. These differences were statistically significant. Conclusion Fasciocutaneous reverse sural artery flap is an excellent choice for reconstruction of the defect at the distal leg and around the ankle region with a high success rate. Below ankle flap reconstruction showed a higher rate of margin necrosis, longer healing time, and less rate of primary healing as compared to the above ankle group. KEY WORDS Above ankle, Below ankle, Fasciocutaneous reverse sural artery flap, Flap take-up, Margin necrosisPublication Drug prescribing pattern and disease pattern in KMC Duwakot Health Center(Kathmandu University, 2004) Bajracharya, S; Pandey, S; Shakya, YLObjective To ascertain the disease pattern and drug prescribing pattern of the patients attending Kathmandu Medical College Health Center, Duwakot. Methods It is a cross sectional study conducted at Kathmandu Medical College (KMC) health Center, Duwakot during the month of Ashad to Mangshir, 2060. The sample size included was 292 patients attending the Health Center during this period. Prescription details were used as study tools to acquire information regarding patient’s name, age, complaints for which consultation was sought, investigations, diagnosis, name of the drug which is prescribed and instruction for diet. Results Age of patients in this study ranged from 0-80 years. A total of 165 (56.50%) were male and 127 (43.49%) were female. Out of 165 male of different age group ranging from 0-80 years, most of the patient i.e. 25(15.15%) were suffering from viral fever followed by cut/injury, allergy, diarrhoea, abdomen pain, fungal infection, HTN (hypertension), cold/cough/sore throat, sinusitis, muscular skeletal pain, joint pain, contact dermatitis, acute peptic disease (APD), headache, worm infestation, tonsillitis, pharyngitis, dizziness, eye infection, chest infection, calf and backache, viral rashes, hypo pigmentation, tension/depression, Urinary tract infection (UTI), coliolilethis, diabetes, p/r bleeding and insect bite poisoning. Out of 127 female of different age group ranging from 0-80 years 21 (16.54%) patients were suffering from viral fever, followed by backache, cold/cough / sore throat, allergy, weakness, acne, diarrhoea, sinusitis, flue, pneumonia, headache, acid peptic disease, dysmenorrhoea, Lower Respiratory Tract Infection and Upper Respiratory Tract Infection, muscular skeletal pain, joint pain, eye infection, Urinary Tract Infection, hypertension, abdomen pain, tonsillitis, tinea corporis, rhinitis, ear problems, insect bite poisoning, CSOM, trichiasis, uteric colic, otitis media, entropion and epiphora, worm infestation and pharyngitis. All together 384 drugs (23 category) were distributed to the different patient of different age group ranging from 0- 80 years, to cure the different types of diseases. Among the different categories of drugs prescribed antipyretic (31.8%), antibiotics (17.2%) and (Non steroid Antiinflammatory Drugs (NSAIDs) (11.2%) were the most common. Conclusion The assessment of the existing prescribing practices in a health facility helps to identify the specific drug use problems, which need to be understood before any meaningful intervention can take place. A prescription provides an insight into a prescriber’s attitude to the disease being treated and the nature of health care delivery system in the community3. The average number of drugs per prescription is an important index of a prescription audit. It is preferable to keep the number of drugs per prescription as low as possible to minimize the risk of drug interactions, development of bacterial resistance and hospital costs 9. Key words: drug prescribing, health centre, disease patternPublication Evaluation of Lipid Peroxidation and Antioxidants’ Status in Metabolic Syndrome(Kathmandu University, 2010) Shrestha, S; Chandra, L; Aryal, M; Das, BKL; Pandey, S; Baral, NABSTRACT Background Metabolic syndrome is a constellation of physical conditions and metabolic abnormalities, commonly occurring together, that increases an individual’s risk for development of type 2 diabetes mellitus and cardiovascular diseases. Oxidative stress is associated with diabetes, hypertension and other cardiovascular diseases while the role of oxidative stress in pathogenesis of MS is not clearly defined. Objectives The study aims to find out the prevalence of metabolic syndrome in faculty and staff members at BP Koirala Institute of Health Sciences, Dharan, Nepal and to evaluate oxidative stress levels in subjects with metabolic syndrome. Methods 118 healthy participants working at B. P. Koirala Institute of Health Sciences, Dharan, Nepal were selected at random for this cross-sectional study and blood samples were collected for the estimation of the following biochemical analytes; fasting glucose; triglycerides; total cholesterol; high density lipoprotein cholesterol; Albumin; uric acid; Bilirubin; Malondialdehyde; Catalase; Glutathione peroxidase; Superoxide Dismutase; Glutathione; vitamin C; and lastly vitamin E. Results In this cross-sectional study, 39% subjects were diagnosed with metabolic syndrome , particularly in sedentary subjects. There was no difference in oxidative stress except significant rises in serum uric acid levels and catalase activity in subjects diagnosed with metabolic syndrome . Conclusion The prevalence of metabolic syndrome is higher without oxidative stress in this study, which suggests that oxidative stress does not contribute to the pathogenesis of MS in otherwise healthy subjects. Key Words antioxidants, lipid peroxidation, metabolic syndrome, oxidative stressPublication Fertility Desire of Working Women in Kathmandu(Nepal Health Research Council, 2010) Pradhan, A; Pandey, SBackground: This study is done to describe the fertility pattern and factors associated with unmet desire for additional children among women working in formal and informal sector in Kathmandu, Nepal. Methods: This is a cross-sectional study. Married 177 women in reproductive age group, with at least one child are selected using purposive sampling. Housewives without paid job are excluded. Interview using semi structured questionnaire is conducted. Results: Around 14 percent of women want additional children however due to various reasons they do not intend to have another. Women in age group of 25-29 followed by 30-34 years of age have higher desire for more children as compared to women in more than 40 years of age. Women who earn 25000-33000 Rupees per month have significantly more desire for another child. Conclusions: Childcare time and economic conditions play vital role in fertility desire among working women. Family help is available to most of the women to care their children. These women wish more facilities at workplace during child bearing and rearing period.Publication Health profile of school children in Bhaktapur(Kathmandu University, 2005) Pandey, S; Dudani, I; Pradhan, AObjectives: To find out the existing common health problems among school children and to arouse health consciousness among the children. Material and methods: All the students studying in Mandev Amrit Smriti School, Jhaukhel VDC of Bhaktapur District were included in the sample. The methods used were the interview, clinical history and check-up for provisional diagnosis. A semi-structured questionnaire was used to record information regarding name, age, sex, standard in which s/he was studying, physical examination/ personal hygiene, anthropometric measurements, clinical findings, provisional diagnosis etc. The medical instruments used in the survey were: weighing machine, measuring tape, and thermometer. Common medicines like Jeevanjal packets, Albendazole tablets for deworming, Metron, amoxicyllin, paracetamol, Tagyl etc were also distributed to the needy students. Results and Conclusion: The physical examination of all 118 students in age group ranging from 3 to 13 years of Mandev Amrit Smriti School situated at Jhaukhel VDc of Bhaktapur district was carried out. Thirteen health related problems were detected in this study. The most important three problems were ear problems (22.03%), worm infestation (16.10%) and dental caries (13.56%). Thus school health education should mainly aim at these problems and the care and cleanliness of ears and teeth by proper and regular brushing should be stressed. Applying Water low classification, 33% males were found normal as per their weight for age. 61.9% males were stunted and 4.8 % males were wasted. Likewise, 54.6% females were found normal as per their weight for age. 43.6% females were stunted and 1.8 % females were wasted. Key Word: School health, Health problemsPublication High risk nonmetastatic persistent gestational trophoblastic tumour following an abortion(Kathmandu University, 2007) Pandey, S; Shrestha, NS; Thapa, MLocally invasive non-metastatic persistent gestational trophoblastic tumours (PGTT) following a non-molar pregnancy occur very rarely. Non-metastatic tumours usually falls in low risk group in WHO scoring system based on prognostic factors. We report a case of high risk non-metastatic PGTT which followed a spontaneous first trimester abortion. Complete remission of the tumour was achieved by chemotherapy EMA-CO regimen. Key words: Persistent gestational trophoblastic tumour, Abortion, ChemotherapyPublication Hysterectomy: an analysis of perioperative and post operative complication(Kathmandu University, 2003) Saha, R; Sharma, M; Padhye, S; Karki, U; Pandey, S; Thapa, JObjective : To document peri operative and post operative complication observed after hysterectomy, regardless of route on the operator. Material and methods: A hospital based prospective study was carried out in department of obstetrics and gynaecology, KMCTH Sinamangal for six months. The study was carried out in patients undergoing hysterectomy who were followed from the time of admission to the time of discharge and two weeks thereafter. And followings were noted-Indication; route of hysterectomy, intraoperative and postoperative morbidities during hospital stay and after two weeks of discharge was noted. Result: Total number of hysterectomy carried out was 50. 31(62%) were Total abdominal hysterectomy, and 19(38%) were vaginal hysterectomy. Indication for total abdominal hysterectomy were fibroid uterus 12(24%), DUB 8 (16%), CIN 4(8%), chronic cervicitis 1 (2%). II U-V prolapse with previous LSCS 1 (2%), endometriosis 1(2%). Prophylactic for Ca breast 1(2%), Postmenopausal bleeding 1(2%). All cases of vaginal hysterectomy were performed for 2nd degree U-V prolapse. Intra operative complication during surgery were two cases of haemorrhage (4%) each in both total abdominal hysterectomy and vaginal hysterectomy. There was one case of bladder injury during abdominal hysterectomy. Postoperative complication noted were febrile morbidity 1(2%) in abdominal hysterectomy. Urinary tract infection remains the single most common febrile morbidity. There was one case of secondary haemorrhage in both type of hysterectomy. One was managed conservatively and other required laprotomy. There were three(6%) cases of wound infection in abdominal hysterectomy of two which were sanguineous discharge and one was frank pus which required secondary suture.Publication Intrauterine Condom Tamponade in Management of Post Partum Haemorrhage(Nepal Health Research Council, 2010) Pandey, S; Amatya, S; Thapa, K; Malla, BBackground: Uterine tamponade is often used to control post partum hemorrhage. Among various methods, condom Foley’s catheter  tamponade is simple, easy to use and is believed to be effective. The study evaluates outcome of condom Foley’s catheter tamponade. Results: The condom tamponade stopped bleeding in all the cases. Average amount of blood loss was 1221ml. No complications were noted. Methods: In this prespective observational study, condom tamponade was applied to fourteen cases with varying degrees of PPH, not controlled with pharmacologic measures. The efficacy on control of bleeding was assessed along with the total amount of blood loss and any complications. Conclusions: Thus, condom tamponade is an effective method to control intractable PPH.  It’s simple and does not require expertise to use, so, it can have a wide application even in resource poor settings.    Key words: condom tamponade, intrauterine, post partum haemorrhagePublication Leflunomide Induced DRESS Syndrome: A Case Report(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2012) Parajuli, S; Chaudhary, D; Pandey, S; Baral, S; Pokhrel, D BNA Keywords: Leflunomide, Dress syndromePublication Management of stroke in emergency department in relationto blood pressure, blood sugar and use of anti-thromboticagents(Institute of Medicine, 2010) Aryal, M; Niraula, S; Shahukhal, R; Mainali, N. R; Sigdel, S; Giri, S; Pandey, S; Shakya, YLAbstract Introduction: Since the Emergency Department (ED) of TUTH lacks uniformity in the treatment of stroke patients, it is assumed that these patients do not receive standard treatment in terms of reduction of blood pressure (BP), control of hyperglycemia and treatment with antithrombotic agents. Our hospital-based study aims to assess the mean stay of stroke patients in the ED and the level of optimal treatment they are getting. Methods: A retrospective hospital-based study among 82 patients diagnosed as CVA in the ED (who later got admitted), was carried out using medical records. History, clinical examinations, investigations and treatment given were analysed to gather relevant information. Results: Mean age of occurrence of stroke in the inpatients visiting ED was found to be 62.4 years. Average duration of stay in the ED before admission was 13 hours. Ischaemic stroke was almost four times more common than haemorrhagic stoke. All the patients with haemorrhagic stroke who had indication for reduction in BP received antihypertensive medications. However, 28% of the patients with ischaemic stroke, even though having indication for BP reduction, did not receive antihypertensives. Out of 11 patients who had an indication for reduction in blood sugar, only one patient (9%) received treatment with insulin. Only 52% of the patients who had ischaemic stroke received treatment with aspirin. Conclusions: There is lack of uniformity regarding the treatment of stroke in terms of blood pressure reduction, hyperglycemia and antithrombotic treatment. A standard protocol needs to be developed in order to bring uniformity and efficiency in the treatment of stroke. Keywords: Anti-thrombotic agents, blood pressure, emergency department, strokePublication Microbiological Analysis of the Urine Isolates in Kathmandu Medical College Teaching Hospital, Kathmandu, Nepal(Kathmandu University, 2011) Raza, S; Pandey, S; Bhatt, CPABSTRACT Background Urinary tract infections (UTIs) are the common cause of bacterial infection. Recently UTI become more complicated and difficult to treat because of appearance of pathogen with increasing resistance to antimicrobial agents. Objective To determine the etiology of the urinary tract infections and their susceptibility to antimicrobial agents. Methods This study was carried out in Kathmandu Medical College, at department of microbiology. Total 3,460 urine samples were tested microbiologically by standard procedure. Antibiotic susceptibility test was performed for all the isolates by Kirby Bauer disc diffusion method and result was interpreted according to National Committee for Clinical Laboratory Standards (NCCLS) guide line. Results Out of 3,460 urine samples 680 (19.7%) showed the significant bacteriuria. The most common pathogens isolated were Escherichia coli 75.7% followed by Klebsiella pneumoniae 10.7%, Acinetobacter spp 5.5%, Proteus spp 3.5% and Pseudomonas aeruginosa 1.2%. Most susceptible antibiotic was Amikacin, Ceftriaxone and Ciprofloxacin for most of the isolates. E. coli which was the main isolate was found to be most susceptible to Amikacin 96.1%, Nitrofurantoin 91.3% and Gentamicin 77.7% followed by Ceftriaxone 65.8% and Ciprofloxacin 64.1%. Conclusion Regular surveillance of the resistance rate among uro-pathogens is needed to ensure the appropriate therapy of UTI. KEY WORDS antibiotic susceptibility, bacteriuria, UTI.Publication One year audit of perinatal mortality at Kathmandu Medical College Hospital(Kathmandu University, 2004) Manandhar, SR; Manandhar, DS; Baral, MR; Pandey, S; Padhey, SIntroduction: Perinatal mortality is a sensitive indicator of the quality of service provided to pregnant women and their new borns. Regular audit of perinatal mortality will help in finding out preventive factors and thus helps in reducing perinatal mortality rate in an institution. Objective: This study was carried out to determine perinatal mortality rate (PMR) and the factors associated with it at KMCTH in the one year period (Bhadra 2059 – Shrawan 2060) Materials and Methods: This is a retrospective study of entire still births and early neonatal deaths that occurred at KMCTH during the one year period (Bhadra 2059 –Shrawan 2060). The study was done by collecting the data of all stillbirths and early neonatal deaths from record books of the Special Care Baby Unit, Labour Room and operation theatre. Results: Out of 563 total births in the one year study period, 17 were still births (SB) and 10 were early neonatal death (ENND). Out of 17 SB, 7 were of < 1 kg and out of 10 ENND, 3 were of < 1 kg. Thus, perinatal mortality rate during the study period was 30.7 and extended perinatal mortality rate was 47.9 per 1000 births. Perinatal deaths were mostly due to extreme prematurity, birth asphyxia, septicemia and congenital anomalies. According to Wiggleworth’s classification, 18.5% of perinatal deaths were in Group I, 14.8 % in Group II, 22.3 % in Group III, 40.7 % in Group IV and 3.7 % in Group V. Intrapartum asphyxia was the commonest cause of perinatal deaths, but majority of these babies were of low birth weight. Prevention of preterm births, better care during intrapartum period, more intensive care of very low birth weight and preterm babies would help in reducing the present high perinatal mortality. Key words: Perinatal Death Audit, Perinatal MortalityPublication Pachydermoperiostosis ('Touraine-Solente-Gole' Syndrome)(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2013) Sharma, R; Pandey, S; Choudhary, D; Pokhrel, DBNo Abstract Keywords: Pachydermia, primary hypertrophic osteoarthropathy, clubbingPublication Participant’s Knowledge and Perception of Health Research Methodology before and after a Hands-on Workshop in a Medical College in Lalitpur, Nepal(Kathmandu University, 2023) Jha, N; Dhakal, AK; Singh, N; Pandey, S; Mukhia, R; Acharya, G; Bajracharya, S; Sharma, MR; Shankar, PRABSTRACT Background The basic principles of research methodology are very important for the successful conduct of research. Objective To evaluate the knowledge and perceptions before and after a three-day workshop on health research methodologies conducted at a medical college in Lalitpur, Nepal. Method The pre-post study was conducted during the workshop. There were 31 participants comprising of doctors (interns and residents), medical officers and dental surgeons and faculties. A questionnaire containing two sections related to various themes of the workshop was developed to measure the respondents’ knowledge and perception of different concepts. Feedback regarding each session was also obtained. The median knowledge and perception scores before and after the workshop were compared using appropriate statistical tests (p < 0.05). Result More than half of the participants, [18 (58.1%)] were of 20-30 years of age. The total knowledge scores improved significantly after the workshop. The increase in the perception scores after the workshop was also significant. Feedback was positive. The highest feedback score was for the session on critical analysis of a published article. Conclusion Knowledge and perceptions increased significantly indicating such workshops can be effective and contribute to the capacity building of the early-stage researchers. KEY WORDS Ethics, Medical research, PublicationPublication Practice of contraceptives(Institute of Medicine, 2009) Pandey, S; Karki, S; Pradhan, AAbstract Introduction: Over the past decades fertility rate have surprisingly been stagnated demanding further research on the ways it reduces rate to a level appropriate for healthy population. Considering the status of male in developing countries like Nepal, it is believed that men play vital role in achieving success in this sector. Therefore this study was done to find out the knowledge and practice of contraceptives among married males of Makwanpur, Nepal. Methods: This is a cross-sectional descriptive study. Data were collected from the 387 respondents by personal interview using semi-structured questionnaire. Results: Mean age of the respondents was 34.48 years. Most of the respondents knew at least four contraceptive methods. There is a strong relationship between knowledge and the use of contraceptives with the level of education and economic status having a direct impact. The attitude of male respondents to share responsibility for promotion of contraceptive was found to be positive. Conclusions: Almost majority agree that the responsibility for contraception should shared by both partner, but use of contraceptive methods among men is still low. This study recommended in depth action research to promote male contraceptive methods and priority for service delivery program in Nepal. Keywords: Contraceptives, family planning, knowledge and practice of contraceptivesPublication Prescription Pattern Monitoring and Off-label Use of Medicines in the Pediatric Department at Tertiary Care Teaching Hospital(Kathmandu University, 2020) Pandey, S; Yadav, CK; Ghimire, P; Shrestha, ACABSTRACT Background Off-label use means the use, concerning dosage, indication, route of administration, or age, of pharmaceutical products which are beyond the terms of the product license. For regulatory bodies and physicians, the global challenge is to achieve optimum pediatric drug therapy. Objective This prospective observational work was carried out in the paediatric department to evaluate the prescribing pattern of medicines and to identify the use of off-label drugs. Method A cross-sectional study was carried in 200 paediatric patients of ages between 0 and 12 years at the paediatric outpatient department of Universal College of Medical Sciences, Bhairahawa. Data were collected by reviewing the prescription paper and the required information was recorded using a structured data collection sheet prepared for study. The prescribing pattern was assessed by using the World Health Organization (WHO) Prescription Indicators and off-label use was assessed using the WHO Children Formulary 2010. Result Among 413 total prescriptions, only 5.56% of drugs were found to be prescribed by generic name, 16.7% of prescriptions were found to be antibiotic and 57.62% of prescribed drugs were from essential drug list. Out of 413 prescribed drugs, 16.46% of drugs were found to be off-label. The maximum extent of off-label prescribing was 51.47% in the child, followed by infants (42.6%) and neonates (5.8%). Fexofenadine; antihistaminic (23.56%), Amoxicillin+clavulanic acid; antibiotic (22.06%) had higher off-label use. Off-label dose (71.8%) was the most common cause of off-label prescribing. Conclusion Off-label prescribing among pediatric patients is common.More eminence data on the safety and efficacy of off-label medicines must be generated to rationalize paediatric pharmacotherapy. KEY WORDS Child, Neonates, Off-label drug use, Pediatric, Prescription pattern monitoring studies (PPMS)Publication Prevalence and Antibiotic Sensitivity Pattern of Methicillin Resistant- Staphylococcus aureus in Kathmandu Medical College –Teaching Hospital(Institute of Medicine, 2012) Pandey, S; Raza, M; Bhatta, CPAbstract Introduction: Staphylococcus aureus is found to be a major source of community as well as hospital acquired infection. Staphylococcal isolates from tertiary care hospital are found to be resistant to commonly used antimicrobial agents. Methicillin resistant S. aureus(MRSA)with intrinsically developed antimicrobial resistance has been associated with an increase in morbidity and mortality of the patients in the hospital. This study was undertaken to know the antibiotic sensitivity pattern of staphylococcal isolates with special reference to Methicillin resistant S. aureus. Methods: Clinical specimens received from July 2009 to July 2010 in Kathmandu Medical college-Teaching Hospital were processed and all S. aureus isolates were included in the study. The isolates were identified by standard laboratory procedure.The antibiotic susceptibility pattern of all staphylococcal strain was determined by modified Kirby Bauer antibiotic sensitivity method. Results: Of 111 S .aureus isolates 29(26.12%)were identifoed to be MRSA. The rate of multi drug resistance was 75.86% for MRSA and 6.09% for MSSA. All the staphylococcal isolates were resistant to penicillin. However, all strains were sensitive to vancomycin. Conclusions: This study showed a high prevalence of MRSA in tertiary care hospital of Kathmandu valley. Regular surveillance of hospital-associated infection and monitoring of antibiotic sensitivity pattern is mandatory to reduce MRSAprevalence in hospital and its spread to community as well. Present study conclusively shows that vancomycin remains the Þrst choice of treatment for MRSAinfection. To preserve its value, use of vancomycin should be limited to those cases where there are clearly needed. Keywords: MRSA, MSSA, Antibiotic Sensitivity, Vancomycin, Staphylococcus aureusPublication Risk Factor Assessment of Multidrug-Resistant Tuberculosis(Nepal Health Research Council, 2009-10) Pandey, S; Pant, R; Pandey, K R; Joshi, M; Sharma, S; Pandey, TPublication Side effects and efficacy of oral mifepristone plus sublingual misoprostol regimen in early medical abortion (gestation up to 63 days)(Institute of Medicine, 2018) Kshetri, R; Bharati, L; Pandey, S; Sapkota, B; Pandey, SAbstract Introduction: Medical abortion with mifepristone and misoprostol has few side effects that cannot be avoided. Efficacy of medical abortion varies with the routes of administration and the doses of mifepristone and misoprostol. This study aimed to investigate the side effects and abortifacient efficacy of 200 mg oral mifepristone and 800 mcg sublingual misoprostol regimen in termination of early pregnancy. Methods: A descriptive cross-sectional study was carried out at Marie Stopes Clinic, Gongabu, Kathmandu. Altogether 103 women with a period of gestation (POG) up to 63 days were selected by purposive sampling technique and were interviewed using two sets of the semi-structured questionnaire. Each woman received 200 mg mifepristone at the clinic. Then 800 mcg misoprostol was taken sublingually at home after 48 hours. Confirmation of abortion was done by ultrasonography. Association between efficacy and POG was calculated by using Chi-square and/or Fisher’s exact test. Results: Side effects reported were nausea, vomiting, diarrhoea, dizziness, fever, chills/shivering, headache, lower abdominal pain, anorexia, lower back pain. The overall efficacy of the regimen was 98.1%. Rates of complete abortion were 98.8% in ≤49 days’ POG and 95.0% in >49days’ POG. The differences were not statistically significant (p-value >0.05). Conclusion: Medical abortion done by using this regimen had few side effects, but no serious side effects or complications were reported. Efficacy of this regimen was high. This study will help to estimate the possible side effects, complications and effectiveness of the given regimen required for proper counselling to the women who opt for medical abortion. Keywords: Efficacy, Medical abortion, Mifepristone, Misoprostol, Side effects, Sublingual