Browsing by Author "SK, Bhattacharya"
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Publication Evaluation of anxiolytic activity of tensarin in mice(Kathmandu University, 2007) GP, Rauniar; S, Deo; SK, BhattacharyaIntroduction: Anxiolytic drugs are amongst the most frequently prescribed drugs. Available anxiolytic agents are associated with several limitations. Several indigenous drugs are being evaluated but none has been proved to be effective. Objectives: Aim of the present study is to evaluate the anxiolytic effect of Tensarin. Material and method: The behavioural tests were conducted with single dose schedule and multiple seven-dose schedules of Tensarin 50mg/kg, 100mg/kg and 200mg/kg in comparison with Diazepam 1mg/kg in mice using open field test, activity-monitoring and passive avoidance test. There were eight treatment groups in each treatment schedule. Each group consisted of ten animals of either sex. The data obtained were analyzed using non- parametric test and P-value of less than 0.05 was considered to be statistically significant. Results: Multiple doses produced anxiolytic effect as indicated by an increase in rearing, number of crossing and the time spent by the animals in Central Square. It was also seen that there was significant decrease in step down latency, increase in step down error and time spent by animal in shock zone, these effects were not observed in single dose study. Conclusion: Tensarin shows a dose dependent anxiolytic effect but further studies are needed to find out the exact mechanism of action of the formulation. Key words: Tensarin, Anxiolytic activity, Open field test, Passive avoidance test.Publication Recent advances in the management of epilepsy: A review(Kathmandu University, 2005) SK, Bhattacharya; GP, Rauniar; BP, DasEpilepsy is a complex disorder affecting brain function having a variety of contributing factors. The genetic predisposition plays a key role in the genesis of epilepsy. The already existing antiepileptic drugs (AEDs) provide effective control of majority of patents with different types of seizures. In some refractory cases and in those patients who can not tolerate the conventional AEDs, there is an urgent need to provide relief by controlling the seizures adequately. Various newer approaches in the rational management of seizures have been evolved during the recent years, based on different mechanisms of action and side effects profile. A brief account of these newer treatment modalities have been incorporated in this review in order to enlighten the readers about the possible beneficial effect of this regimen vis a vis the limitations of such use. Keywords: Neurotransmitter imbalance, defective gene, newer antiepileptic drugs, plasma levels, newer approaches.Publication Vagus nerve stimulation: A novel approach for prevention and control of refractory seizures(Kathmandu University, 2007) SK, Bhattacharya; BP, Das; GP, Rauniar; H, SangraulaIn order to understand the brain function and to treat various neuropsychiatric illnesses including epilepsy, continued search and discovery of newer antiepileptic drugs has failed to revolutionize the approach in the management of this complex disorder. Moreover, in close to 30% of epilepsy patients, the seizure control is either not satisfactory or it is intractable to pharmacotherapy. Amongst the non-pharmacological treatment options for refractory epilepsy, vagus nerve stimulation occupies a unique position as an adjunctive treatment in prevention and control of partial-onset seizures in adults and adolescents older than 12 years. Though the precise mode of action of VNS is still debatable an honest attempt has been mode here to review all possible literatures available on VNS to establish its role in the management of this complex disorder. Key words: Neuropsychiatric illness, Intractable Epilepsy, Vagus nerve stimulation, Seizure control