Publication: Pemphigus herpetiformis : A rare clinical variant of pemphigus
Date
2015
Authors
Article Type
Case Report
Journal Title
Journal ISSN
ISSN 2091-0231 eISSN 2091-167X
Volume Title
Pages
Pages: 61 - 65
Publisher
Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)
Abstract
Abstract:
Pemphigus herpetiformis is an autoimmune blistering disease. We report a case of pemphigus herpetiformis, a generalized form, manifested as pruritic grouped vesicles at extremities and trunk, in a seventy years old man. Neutrophil dominant inflammatory substrate was seen in histopathology. Direct immunofluorescene revealed IgG reactivity in net like pattern at upper epidermis, confirming pemphigus. The patient responded well to prednisolone and colchicine combination initially and maintained remission later on colchicine alone. Colchicine has anti-mitotic, anti-inflammatory and immunosuppressive mechanism of actions and proven benefits in neutrophilic dermatoses. Therefore we recommend colchicine as mono therapy or in combination with immunosuppressive, for the treatment of pemphigus herpetiformis where neutrophil is predominant inflammatory infiltrate histologically.
Keywords: Pemphigus, Herpetiform, Pruritic, Vesicles
Description
P Shrestha
Department of Dermatology, Vayodha Hospital Pvt. Ltd, Balkhu, Kathmandu
R B Tajhya
Department of Dermatology, Vayodha Hospital Pvt. Ltd, Balkhu, Kathmandu
A Pokharel
Department of Dermatology, Chitwan Medical College, Bharatpur
Keywords
Identifier
https://doi.org/10.3126/njdvl.v13i1.14308