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Prevalence of Hepatitis B and C among HIV Infected Patients in Nepal over 1990-2020

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creativeworkseries.issn1812-2027
dc.contributor.authorShrestha, DB
dc.contributor.authorBudhathoki, P
dc.contributor.authorSedhai, YR
dc.contributor.authorShrestha, LB
dc.contributor.authorAwal, S
dc.contributor.authorUpadhaya Regmi, B
dc.contributor.authorYadav, J
dc.contributor.authorBaniya, R
dc.contributor.authorThapaliya, S
dc.contributor.authorDangal, G
dc.date.accessioned2025-12-11T07:23:23Z
dc.date.available2025-12-11T07:23:23Z
dc.date.issued2021
dc.descriptionShrestha DB,1 Budhathoki P,2 Sedhai YR,3 Shrestha LB,4 Awal S,5 Upadhaya Regmi B,5 Yadav J,5 Baniya R,6 Thapaliya S,7 Dangal G8 1Department of Emergency Medicine, Mangalbare Hospital, Morang-56600, Nepal 2Department of Emergency Medicine, Dr. Iwamura Memorial Hospital, Bhaktapur-44800, Nepal 3Department of Internal Medicine, Division of Hospital Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA, USA 4Department of Microbiology and Infectious Diseases, B. P. Koirala Institute of Health Sciences, Dharan, Nepal 5Nepalese Army Institute of Health Sciences, Kathmandu, Nepal. 6Our Lady of the Lake Regional Medical Center, Baton Rouge, LA, USA 7Department of Internal Medicine, Division of Infectious Disease, Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Nepal 8Department of Obstetrics and Gynecology, National Academy of Medical Sciences, Kathmandu, Nepal
dc.description.abstractABSTRACT Background Hepatitis B and C (HBV and HCV) are viral infections caused by corresponding viruses. Here in this study we planned to conduct this meta-analysis to pool data on the prevalence and risk factors of HBV and/or HCV among HIV patients in Nepal. Method We used MOOSE guideline for the systemic review of available literature. We searched online databases using appropriate keywords. We used CMA-3 for data synthesis. Odds ratio, and proportion were used to estimate the outcome with a 95% confidence interval where appropriate. We assessed the heterogeneity using the I-squared (I2) test. Result We included nine studies for our synthesis. Pooling of data showed HBV in 4.6% (CI: 3.7-5.6), HCV in 19.7% (CI: 10.8-33.0), both HBV and HCV in 1.3% (CI: 0.5-3.7) in HIV affected individuals. Among HBV co-infected HIV positive patients, 59.5% (CI: 25.5-86.3) were male; 76.1% (CI: 30.1-96.0) were married and 43.6% (CI: 3.8-93.8) had a history of intravenous drug use (IVDU). Among HCV co-infected HIV positive individuals 88.3% (CI: 73.6-95.4) were male; 63.6% (CI: 55.4-71.1) were married; 91.5% (CI: 68.6-98.1) were literate; 59.2% (CI: 49.9-67.9) were on ART; and 92.2% (95%CI: 84.9-96.1) had a history of IVDU. Conclusion The pooled prevalence of co-infection with HBV, HCV, and combined HBV and HCV were 4.6%, 19.7% and 1.3% respectively among HIV positive patients. Thus, it is necessary to appropriately screen for HBV and HCV in individuals diagnosed with HIV and high-risk populations. IVDU remains the most common risk factor found in co-infected individuals. KEY WORDS Coinfection, Hepatitis B, Hepatitis C, HIV Infection, Intravenous, Substance abuse
dc.identifier.urihttps://hdl.handle.net/20.500.14572/3543
dc.language.isoen_US
dc.publisherKathmandu University
dc.subjectCoinfection
dc.subjectHepatitis B
dc.subjectHepatitis C
dc.subjectHIV Infection
dc.subjectIntravenous
dc.subjectSubstance abuse
dc.titlePrevalence of Hepatitis B and C among HIV Infected Patients in Nepal over 1990-2020
dc.typeArticle
dspace.entity.typePublication
local.article.typeReview Article
oaire.citation.endPage139
oaire.citation.startPage132
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relation.isJournalIssueOfPublication.latestForDiscoverydd71608f-309e-4987-a5c2-264b37b74bcb
relation.isJournalOfPublicationa782b7ff-cf89-4178-ad1c-11ed89cfe1bd

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