Publication: Transient Abnormal Myelopoiesis in a Neonate without Down Syndrome
Date
2017
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Nepal Paediatric Society (JNPS)
Abstract
Abstract:
Transient abnormal myelopoiesis (TAM) also known as transient myeloproliferative disorder (TMD), a unique transient neonatal preleukaemic disorder characterized by clonal proliferation of megakaryoblasts, has been usually described to be associated with Down syndrome neonates. However, there are case reports of it occurring in neonates without Down phenotype, who are either mosaic for trisomy 21 or have trisomy 21 restricted to leukemic clone. This case report presents a case of TAM in a phenotypically normal neonate who presented in respiratory distress with features of tumour lysis syndrome (TLS) immediately after birth who was treated symptomatically and had spontaneous remission within three months.
Description
Rupesh Shrestha
Midat Hospital, Lagankhel, Lalitpur
http://orcid.org/0000-0002-8027-5041
Keywords
Immunophenotype, morphology, transient abnormal myelopoiesis, trisomy 21, GATA1 gene, tumour lysis syndrome