Transient Abnormal Myelopoiesis in a Neonate without Down Syndrome

Shrestha, Rupesh

Publication:
Transient Abnormal Myelopoiesis in a Neonate without Down Syndrome

creativeworkseries.issn	ISSN 1990-7974 eISSN 1990-7982
dc.contributor.author	Shrestha, Rupesh
dc.date.accessioned	2026-02-04T05:22:04Z
dc.date.available	2026-02-04T05:22:04Z
dc.date.issued	2017
dc.description	Rupesh Shrestha Midat Hospital, Lagankhel, Lalitpur http://orcid.org/0000-0002-8027-5041
dc.description.abstract	Abstract: Transient abnormal myelopoiesis (TAM) also known as transient myeloproliferative disorder (TMD), a unique transient neonatal preleukaemic disorder characterized by clonal proliferation of megakaryoblasts, has been usually described to be associated with Down syndrome neonates. However, there are case reports of it occurring in neonates without Down phenotype, who are either mosaic for trisomy 21 or have trisomy 21 restricted to leukemic clone. This case report presents a case of TAM in a phenotypically normal neonate who presented in respiratory distress with features of tumour lysis syndrome (TLS) immediately after birth who was treated symptomatically and had spontaneous remission within three months.
dc.identifier	https://doi.org/10.3126/jnps.v37i3.19186
dc.identifier.uri	https://hdl.handle.net/20.500.14572/4491
dc.language.iso	en_US
dc.publisher	Nepal Paediatric Society (JNPS)
dc.subject	Immunophenotype
dc.subject	morphology
dc.subject	transient abnormal myelopoiesis
dc.subject	trisomy 21
dc.subject	GATA1 gene
dc.subject	tumour lysis syndrome
dc.title	Transient Abnormal Myelopoiesis in a Neonate without Down Syndrome
dc.type	Article
dspace.entity.type	Publication
local.article.type	Case Report
oaire.citation.endPage	299
oaire.citation.startPage	296
relation.isJournalIssueOfPublication	97340c14-0d1f-4808-806c-8504b2e33439
relation.isJournalIssueOfPublication.latestForDiscovery	97340c14-0d1f-4808-806c-8504b2e33439
relation.isJournalOfPublication	6f9be05c-05a9-4a3e-a5b5-a19a15ab042c