Publication: Knuckle Pigmentation as an Early Cutaneous Sign of Vitamin B12 Deficiency: A Case Report
Date
2020
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Nepal Medical Association
Abstract
Abstracts:
Vitamin B12 deficiency can present with variable hematological, neuropsychiatric, and mucocutaneous changes. Hyperpigmentation, specifically involving the knuckles has been described in vitamin B12 deficiency, but usually,these patients are symptomatic with systemic manifestations like megaloblastic anemia, pancytopenia, or neurological deficits. Here, we are reporting a case of nutritional vitamin B12 deficiency, who presented with isolated knuckle pigmentation and was successfully treated with oral therapy. This case also highlights the importance of recognizing this cutaneous sign as an early marker of vitamin B12 deficiency; thereby enabling the clinician to treat the disease before it leads to irreversible neurological complications.
Description
Ankita Srivastava
Department of Dermatology, All India Institute of Medical Sciences, Nagpur, Maharashtra, India
Sanjiv Choudhary
Department of Dermatology, All India Institute of Medical Sciences, Nagpur, Maharashtra, India
Keywords
knuckle pigmentation, treatment, vitamin B12 deficiency